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Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors
Eph receptors are the largest family of receptor tyrosine kinases and by interactions with ephrin ligands mediate a myriad of processes from embryonic development to adult tissue homeostasis. The interaction of Eph receptors, especially at their transmembrane (TM) domains is key to understanding the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395321/ https://www.ncbi.nlm.nih.gov/pubmed/34445298 http://dx.doi.org/10.3390/ijms22168593 |
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author | Sahoo, Amita R. Buck, Matthias |
author_facet | Sahoo, Amita R. Buck, Matthias |
author_sort | Sahoo, Amita R. |
collection | PubMed |
description | Eph receptors are the largest family of receptor tyrosine kinases and by interactions with ephrin ligands mediate a myriad of processes from embryonic development to adult tissue homeostasis. The interaction of Eph receptors, especially at their transmembrane (TM) domains is key to understanding their mechanism of signal transduction across cellular membranes. We review the structural and functional aspects of EphA1/A2 association and the techniques used to investigate their TM domains: NMR, molecular modelling/dynamics simulations and fluorescence. We also introduce transmembrane peptides, which can be used to alter Eph receptor signaling and we provide a perspective for future studies. |
format | Online Article Text |
id | pubmed-8395321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83953212021-08-28 Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors Sahoo, Amita R. Buck, Matthias Int J Mol Sci Review Eph receptors are the largest family of receptor tyrosine kinases and by interactions with ephrin ligands mediate a myriad of processes from embryonic development to adult tissue homeostasis. The interaction of Eph receptors, especially at their transmembrane (TM) domains is key to understanding their mechanism of signal transduction across cellular membranes. We review the structural and functional aspects of EphA1/A2 association and the techniques used to investigate their TM domains: NMR, molecular modelling/dynamics simulations and fluorescence. We also introduce transmembrane peptides, which can be used to alter Eph receptor signaling and we provide a perspective for future studies. MDPI 2021-08-10 /pmc/articles/PMC8395321/ /pubmed/34445298 http://dx.doi.org/10.3390/ijms22168593 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sahoo, Amita R. Buck, Matthias Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title | Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title_full | Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title_fullStr | Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title_full_unstemmed | Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title_short | Structural and Functional Insights into the Transmembrane Domain Association of Eph Receptors |
title_sort | structural and functional insights into the transmembrane domain association of eph receptors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395321/ https://www.ncbi.nlm.nih.gov/pubmed/34445298 http://dx.doi.org/10.3390/ijms22168593 |
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