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The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System

Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards legalization and lack of consistent, evidence-based knowledge on the matter. While there is conflicting data regarding whether cannabis use during pregnancy leads to adverse out...

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Autores principales: Martínez-Peña, Annia A., Perono, Genevieve A., Gritis, Sarah Alexis, Sharma, Reeti, Selvakumar, Shamini, Walker, O’Llenecia S., Gurm, Harmeet, Holloway, Alison C., Raha, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395329/
https://www.ncbi.nlm.nih.gov/pubmed/34445282
http://dx.doi.org/10.3390/ijms22168576
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author Martínez-Peña, Annia A.
Perono, Genevieve A.
Gritis, Sarah Alexis
Sharma, Reeti
Selvakumar, Shamini
Walker, O’Llenecia S.
Gurm, Harmeet
Holloway, Alison C.
Raha, Sandeep
author_facet Martínez-Peña, Annia A.
Perono, Genevieve A.
Gritis, Sarah Alexis
Sharma, Reeti
Selvakumar, Shamini
Walker, O’Llenecia S.
Gurm, Harmeet
Holloway, Alison C.
Raha, Sandeep
author_sort Martínez-Peña, Annia A.
collection PubMed
description Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards legalization and lack of consistent, evidence-based knowledge on the matter. While there is conflicting data regarding whether cannabis use during pregnancy leads to adverse outcomes such as stillbirth, preterm birth, low birthweight, or increased admission to neonatal intensive care units, investigations into long-term effects on the offspring’s health are limited. Historically, studies have focused on the neurobehavioral effects of prenatal cannabis exposure on the offspring. The effects of cannabis on other physiological aspects of the developing fetus have received less attention. Importantly, our knowledge about cannabinoid signaling in the placenta is also limited. The endocannabinoid system (ECS) is present at early stages of development and represents a potential target for exogenous cannabinoids in utero. The ECS is expressed in a broad range of tissues and influences a spectrum of cellular functions. The aim of this review is to explore the current evidence surrounding the effects of prenatal exposure to cannabinoids and the role of the ECS in the placenta and the developing fetus.
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spelling pubmed-83953292021-08-28 The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System Martínez-Peña, Annia A. Perono, Genevieve A. Gritis, Sarah Alexis Sharma, Reeti Selvakumar, Shamini Walker, O’Llenecia S. Gurm, Harmeet Holloway, Alison C. Raha, Sandeep Int J Mol Sci Review Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards legalization and lack of consistent, evidence-based knowledge on the matter. While there is conflicting data regarding whether cannabis use during pregnancy leads to adverse outcomes such as stillbirth, preterm birth, low birthweight, or increased admission to neonatal intensive care units, investigations into long-term effects on the offspring’s health are limited. Historically, studies have focused on the neurobehavioral effects of prenatal cannabis exposure on the offspring. The effects of cannabis on other physiological aspects of the developing fetus have received less attention. Importantly, our knowledge about cannabinoid signaling in the placenta is also limited. The endocannabinoid system (ECS) is present at early stages of development and represents a potential target for exogenous cannabinoids in utero. The ECS is expressed in a broad range of tissues and influences a spectrum of cellular functions. The aim of this review is to explore the current evidence surrounding the effects of prenatal exposure to cannabinoids and the role of the ECS in the placenta and the developing fetus. MDPI 2021-08-09 /pmc/articles/PMC8395329/ /pubmed/34445282 http://dx.doi.org/10.3390/ijms22168576 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martínez-Peña, Annia A.
Perono, Genevieve A.
Gritis, Sarah Alexis
Sharma, Reeti
Selvakumar, Shamini
Walker, O’Llenecia S.
Gurm, Harmeet
Holloway, Alison C.
Raha, Sandeep
The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title_full The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title_fullStr The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title_full_unstemmed The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title_short The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
title_sort impact of early life exposure to cannabis: the role of the endocannabinoid system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395329/
https://www.ncbi.nlm.nih.gov/pubmed/34445282
http://dx.doi.org/10.3390/ijms22168576
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