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Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors

The discovery that receptors from all families can establish allosteric receptor–receptor interactions and variably associate to form receptor complexes operating as integrative input units endowed with a high functional and structural plasticity has expanded our understanding of intercellular commu...

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Detalles Bibliográficos
Autores principales: Guidolin, Diego, Tortorella, Cinzia, Marcoli, Manuela, Cervetto, Chiara, Maura, Guido, Agnati, Luigi F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395429/
https://www.ncbi.nlm.nih.gov/pubmed/34445362
http://dx.doi.org/10.3390/ijms22168656
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author Guidolin, Diego
Tortorella, Cinzia
Marcoli, Manuela
Cervetto, Chiara
Maura, Guido
Agnati, Luigi F.
author_facet Guidolin, Diego
Tortorella, Cinzia
Marcoli, Manuela
Cervetto, Chiara
Maura, Guido
Agnati, Luigi F.
author_sort Guidolin, Diego
collection PubMed
description The discovery that receptors from all families can establish allosteric receptor–receptor interactions and variably associate to form receptor complexes operating as integrative input units endowed with a high functional and structural plasticity has expanded our understanding of intercellular communication. Regarding the nervous system, most research in the field has focused on neuronal populations and has led to the identification of many receptor complexes representing an important mechanism to fine-tune synaptic efficiency. Receptor–receptor interactions, however, also modulate glia–neuron and glia–glia intercellular communication, with significant consequences on synaptic activity and brain network plasticity. The research on this topic is probably still at the beginning and, here, available evidence will be reviewed and discussed. It may also be of potential interest from a pharmacological standpoint, opening the possibility to explore, inter alia, glia-based neuroprotective therapeutic strategies.
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spelling pubmed-83954292021-08-28 Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors Guidolin, Diego Tortorella, Cinzia Marcoli, Manuela Cervetto, Chiara Maura, Guido Agnati, Luigi F. Int J Mol Sci Review The discovery that receptors from all families can establish allosteric receptor–receptor interactions and variably associate to form receptor complexes operating as integrative input units endowed with a high functional and structural plasticity has expanded our understanding of intercellular communication. Regarding the nervous system, most research in the field has focused on neuronal populations and has led to the identification of many receptor complexes representing an important mechanism to fine-tune synaptic efficiency. Receptor–receptor interactions, however, also modulate glia–neuron and glia–glia intercellular communication, with significant consequences on synaptic activity and brain network plasticity. The research on this topic is probably still at the beginning and, here, available evidence will be reviewed and discussed. It may also be of potential interest from a pharmacological standpoint, opening the possibility to explore, inter alia, glia-based neuroprotective therapeutic strategies. MDPI 2021-08-12 /pmc/articles/PMC8395429/ /pubmed/34445362 http://dx.doi.org/10.3390/ijms22168656 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guidolin, Diego
Tortorella, Cinzia
Marcoli, Manuela
Cervetto, Chiara
Maura, Guido
Agnati, Luigi F.
Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title_full Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title_fullStr Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title_full_unstemmed Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title_short Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors
title_sort receptor–receptor interactions and glial cell functions with a special focus on g protein-coupled receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395429/
https://www.ncbi.nlm.nih.gov/pubmed/34445362
http://dx.doi.org/10.3390/ijms22168656
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