Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. DPYD gene sequencing revealed rare...

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Autores principales: Bukhari, Nedal, Alshangiti, Abdulraheem, Tashkandi, Emad, Algarni, Mohammed, Al-Shamsi, Humaid O., Al-Khallaf, Hamoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395516/
https://www.ncbi.nlm.nih.gov/pubmed/34449540
http://dx.doi.org/10.3390/clinpract11030062
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author Bukhari, Nedal
Alshangiti, Abdulraheem
Tashkandi, Emad
Algarni, Mohammed
Al-Shamsi, Humaid O.
Al-Khallaf, Hamoud
author_facet Bukhari, Nedal
Alshangiti, Abdulraheem
Tashkandi, Emad
Algarni, Mohammed
Al-Shamsi, Humaid O.
Al-Khallaf, Hamoud
author_sort Bukhari, Nedal
collection PubMed
description Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. DPYD gene sequencing revealed rare different polymorphisms that prompted dose adjustments of administered 5-FU and capecitabine. To our knowledge, this is the first case series looking at DPYD polymorphisms in the Saudi Arabian population.
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spelling pubmed-83955162021-08-28 Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature Bukhari, Nedal Alshangiti, Abdulraheem Tashkandi, Emad Algarni, Mohammed Al-Shamsi, Humaid O. Al-Khallaf, Hamoud Clin Pract Article Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. DPYD gene sequencing revealed rare different polymorphisms that prompted dose adjustments of administered 5-FU and capecitabine. To our knowledge, this is the first case series looking at DPYD polymorphisms in the Saudi Arabian population. MDPI 2021-07-27 /pmc/articles/PMC8395516/ /pubmed/34449540 http://dx.doi.org/10.3390/clinpract11030062 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bukhari, Nedal
Alshangiti, Abdulraheem
Tashkandi, Emad
Algarni, Mohammed
Al-Shamsi, Humaid O.
Al-Khallaf, Hamoud
Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title_full Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title_fullStr Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title_full_unstemmed Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title_short Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature
title_sort fluoropyrimidine-induced severe toxicities associated with rare dpyd polymorphisms: case series from saudi arabia and a review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395516/
https://www.ncbi.nlm.nih.gov/pubmed/34449540
http://dx.doi.org/10.3390/clinpract11030062
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