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Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based chemotherapy. DPYD gene sequencing revealed rare...

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Detalles Bibliográficos
Autores principales:	Bukhari, Nedal, Alshangiti, Abdulraheem, Tashkandi, Emad, Algarni, Mohammed, Al-Shamsi, Humaid O., Al-Khallaf, Hamoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395516/ https://www.ncbi.nlm.nih.gov/pubmed/34449540 http://dx.doi.org/10.3390/clinpract11030062

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