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Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response

A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of...

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Autores principales: Grubmüller, Bernhard, Jahrreiss, Victoria, Brönimann, Stephan, Quhal, Fahad, Mori, Keiichiro, Heidenreich, Axel, Briganti, Alberto, Tilki, Derya, Shariat, Shahrokh F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395524/
https://www.ncbi.nlm.nih.gov/pubmed/34436018
http://dx.doi.org/10.3390/curroncol28040252
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author Grubmüller, Bernhard
Jahrreiss, Victoria
Brönimann, Stephan
Quhal, Fahad
Mori, Keiichiro
Heidenreich, Axel
Briganti, Alberto
Tilki, Derya
Shariat, Shahrokh F.
author_facet Grubmüller, Bernhard
Jahrreiss, Victoria
Brönimann, Stephan
Quhal, Fahad
Mori, Keiichiro
Heidenreich, Axel
Briganti, Alberto
Tilki, Derya
Shariat, Shahrokh F.
author_sort Grubmüller, Bernhard
collection PubMed
description A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January 1980 and April 2020. Overall, 23 English language articles including a total number of 2323 patients were selected according to PRISMA criteria. The overall median follow-up was 37.5 months (IQR 35.5–52.5). Biochemical-recurrence (BCR)-free probability ranged from 34% to 83% at five years, respectively, and from 31% to 37% at 10 years. Cancer specific survival (CSS) and overall survival (OS) ranged from 88.7% to 98% and 64% to 95% at five years and from 72% to 83% and 65% to 72% at 10 years, respectively. Positive surgical margins ranged from 14% to 45.8% and pathologic organ-confined disease was reported from 20% to 57%. The rate of pathologic > T2-disease ranged from 37% to 80% and pN1 disease differed between 0% to 78.4%. Pre-SRP PSA, pre-SRP Gleason Score (GS), pathologic stage after SRP, and pathologic lymph node involvement seemed to be the strongest prognostic factors for good outcomes. SRP provides accurate histopathological and functional outcomes, as well as durable cancer control. Careful patient counseling in a shared decision-making process is recommended.
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spelling pubmed-83955242021-08-28 Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response Grubmüller, Bernhard Jahrreiss, Victoria Brönimann, Stephan Quhal, Fahad Mori, Keiichiro Heidenreich, Axel Briganti, Alberto Tilki, Derya Shariat, Shahrokh F. Curr Oncol Systematic Review A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January 1980 and April 2020. Overall, 23 English language articles including a total number of 2323 patients were selected according to PRISMA criteria. The overall median follow-up was 37.5 months (IQR 35.5–52.5). Biochemical-recurrence (BCR)-free probability ranged from 34% to 83% at five years, respectively, and from 31% to 37% at 10 years. Cancer specific survival (CSS) and overall survival (OS) ranged from 88.7% to 98% and 64% to 95% at five years and from 72% to 83% and 65% to 72% at 10 years, respectively. Positive surgical margins ranged from 14% to 45.8% and pathologic organ-confined disease was reported from 20% to 57%. The rate of pathologic > T2-disease ranged from 37% to 80% and pN1 disease differed between 0% to 78.4%. Pre-SRP PSA, pre-SRP Gleason Score (GS), pathologic stage after SRP, and pathologic lymph node involvement seemed to be the strongest prognostic factors for good outcomes. SRP provides accurate histopathological and functional outcomes, as well as durable cancer control. Careful patient counseling in a shared decision-making process is recommended. MDPI 2021-07-29 /pmc/articles/PMC8395524/ /pubmed/34436018 http://dx.doi.org/10.3390/curroncol28040252 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Grubmüller, Bernhard
Jahrreiss, Victoria
Brönimann, Stephan
Quhal, Fahad
Mori, Keiichiro
Heidenreich, Axel
Briganti, Alberto
Tilki, Derya
Shariat, Shahrokh F.
Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title_full Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title_fullStr Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title_full_unstemmed Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title_short Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response
title_sort salvage radical prostatectomy for radio-recurrent prostate cancer: an updated systematic review of oncologic, histopathologic and functional outcomes and predictors of good response
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395524/
https://www.ncbi.nlm.nih.gov/pubmed/34436018
http://dx.doi.org/10.3390/curroncol28040252
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