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Granular Cell Dermatofibroma: When Morphology Still Matters
Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of diffe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395898/ https://www.ncbi.nlm.nih.gov/pubmed/34449582 http://dx.doi.org/10.3390/dermatopathology8030041 |
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author | Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Marrone, Maricla Stellacci, Alessandra Arezzo, Francesca Lettini, Teresa Resta, Leonardo Ingravallo, Giuseppe |
author_facet | Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Marrone, Maricla Stellacci, Alessandra Arezzo, Francesca Lettini, Teresa Resta, Leonardo Ingravallo, Giuseppe |
author_sort | Cazzato, Gerardo |
collection | PubMed |
description | Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman. |
format | Online Article Text |
id | pubmed-8395898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83958982021-08-28 Granular Cell Dermatofibroma: When Morphology Still Matters Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Marrone, Maricla Stellacci, Alessandra Arezzo, Francesca Lettini, Teresa Resta, Leonardo Ingravallo, Giuseppe Dermatopathology (Basel) Communication Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman. MDPI 2021-08-13 /pmc/articles/PMC8395898/ /pubmed/34449582 http://dx.doi.org/10.3390/dermatopathology8030041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Marrone, Maricla Stellacci, Alessandra Arezzo, Francesca Lettini, Teresa Resta, Leonardo Ingravallo, Giuseppe Granular Cell Dermatofibroma: When Morphology Still Matters |
title | Granular Cell Dermatofibroma: When Morphology Still Matters |
title_full | Granular Cell Dermatofibroma: When Morphology Still Matters |
title_fullStr | Granular Cell Dermatofibroma: When Morphology Still Matters |
title_full_unstemmed | Granular Cell Dermatofibroma: When Morphology Still Matters |
title_short | Granular Cell Dermatofibroma: When Morphology Still Matters |
title_sort | granular cell dermatofibroma: when morphology still matters |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395898/ https://www.ncbi.nlm.nih.gov/pubmed/34449582 http://dx.doi.org/10.3390/dermatopathology8030041 |
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