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Granular Cell Dermatofibroma: When Morphology Still Matters

Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of diffe...

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Autores principales: Cazzato, Gerardo, Colagrande, Anna, Cimmino, Antonietta, Marrone, Maricla, Stellacci, Alessandra, Arezzo, Francesca, Lettini, Teresa, Resta, Leonardo, Ingravallo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395898/
https://www.ncbi.nlm.nih.gov/pubmed/34449582
http://dx.doi.org/10.3390/dermatopathology8030041
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author Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Marrone, Maricla
Stellacci, Alessandra
Arezzo, Francesca
Lettini, Teresa
Resta, Leonardo
Ingravallo, Giuseppe
author_facet Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Marrone, Maricla
Stellacci, Alessandra
Arezzo, Francesca
Lettini, Teresa
Resta, Leonardo
Ingravallo, Giuseppe
author_sort Cazzato, Gerardo
collection PubMed
description Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.
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spelling pubmed-83958982021-08-28 Granular Cell Dermatofibroma: When Morphology Still Matters Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Marrone, Maricla Stellacci, Alessandra Arezzo, Francesca Lettini, Teresa Resta, Leonardo Ingravallo, Giuseppe Dermatopathology (Basel) Communication Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman. MDPI 2021-08-13 /pmc/articles/PMC8395898/ /pubmed/34449582 http://dx.doi.org/10.3390/dermatopathology8030041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Marrone, Maricla
Stellacci, Alessandra
Arezzo, Francesca
Lettini, Teresa
Resta, Leonardo
Ingravallo, Giuseppe
Granular Cell Dermatofibroma: When Morphology Still Matters
title Granular Cell Dermatofibroma: When Morphology Still Matters
title_full Granular Cell Dermatofibroma: When Morphology Still Matters
title_fullStr Granular Cell Dermatofibroma: When Morphology Still Matters
title_full_unstemmed Granular Cell Dermatofibroma: When Morphology Still Matters
title_short Granular Cell Dermatofibroma: When Morphology Still Matters
title_sort granular cell dermatofibroma: when morphology still matters
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395898/
https://www.ncbi.nlm.nih.gov/pubmed/34449582
http://dx.doi.org/10.3390/dermatopathology8030041
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