Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation

Peptide-based target protein degradation inducers called PROTACs/SNIPERs have low cell penetrability and poor intracellular stability as drawbacks. These shortcomings can be overcome by easily modifying these peptides by conjugation with cell penetrating peptides and side-chain stapling. In this stu...

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Detalles Bibliográficos
Autores principales: Yokoo, Hidetomo, Ohoka, Nobumichi, Takyo, Mami, Ito, Takahito, Tsuchiya, Keisuke, Kurohara, Takashi, Fukuhara, Kiyoshi, Inoue, Takao, Naito, Mikihiko, Demizu, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396023/
https://www.ncbi.nlm.nih.gov/pubmed/34445478
http://dx.doi.org/10.3390/ijms22168772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396023/
https://www.ncbi.nlm.nih.gov/pubmed/34445478
http://dx.doi.org/10.3390/ijms22168772

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