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The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets

Mitochondria-derived peptides (MDPs) are small peptides hidden in the mitochondrial DNA, maintaining mitochondrial function and protecting cells under different stresses. Currently, three types of MDPs have been identified: Humanin, MOTS-c and SHLP1-6. MDPs have demonstrated anti-apoptotic and anti-...

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Autores principales: Dabravolski, Siarhei A., Nikiforov, Nikita G., Starodubova, Antonina V., Popkova, Tatyana V., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396025/
https://www.ncbi.nlm.nih.gov/pubmed/34445477
http://dx.doi.org/10.3390/ijms22168770
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author Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Starodubova, Antonina V.
Popkova, Tatyana V.
Orekhov, Alexander N.
author_facet Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Starodubova, Antonina V.
Popkova, Tatyana V.
Orekhov, Alexander N.
author_sort Dabravolski, Siarhei A.
collection PubMed
description Mitochondria-derived peptides (MDPs) are small peptides hidden in the mitochondrial DNA, maintaining mitochondrial function and protecting cells under different stresses. Currently, three types of MDPs have been identified: Humanin, MOTS-c and SHLP1-6. MDPs have demonstrated anti-apoptotic and anti-inflammatory activities, reactive oxygen species and oxidative stress-protecting properties both in vitro and in vivo. Recent research suggests that MDPs have a significant cardioprotective role, affecting CVDs (cardiovascular diseases) development and progression. CVDs are the leading cause of death globally; this term combines disorders of the blood vessels and heart. In this review, we focus on the recent progress in understanding the relationships between MDPs and the main cardiovascular risk factors (atherosclerosis, insulin resistance, hyperlipidaemia and ageing). We also will discuss the therapeutic application of MDPs, modified and synthetic MDPs, and their potential as novel biomarkers and therapeutic targets.
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spelling pubmed-83960252021-08-28 The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets Dabravolski, Siarhei A. Nikiforov, Nikita G. Starodubova, Antonina V. Popkova, Tatyana V. Orekhov, Alexander N. Int J Mol Sci Review Mitochondria-derived peptides (MDPs) are small peptides hidden in the mitochondrial DNA, maintaining mitochondrial function and protecting cells under different stresses. Currently, three types of MDPs have been identified: Humanin, MOTS-c and SHLP1-6. MDPs have demonstrated anti-apoptotic and anti-inflammatory activities, reactive oxygen species and oxidative stress-protecting properties both in vitro and in vivo. Recent research suggests that MDPs have a significant cardioprotective role, affecting CVDs (cardiovascular diseases) development and progression. CVDs are the leading cause of death globally; this term combines disorders of the blood vessels and heart. In this review, we focus on the recent progress in understanding the relationships between MDPs and the main cardiovascular risk factors (atherosclerosis, insulin resistance, hyperlipidaemia and ageing). We also will discuss the therapeutic application of MDPs, modified and synthetic MDPs, and their potential as novel biomarkers and therapeutic targets. MDPI 2021-08-16 /pmc/articles/PMC8396025/ /pubmed/34445477 http://dx.doi.org/10.3390/ijms22168770 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dabravolski, Siarhei A.
Nikiforov, Nikita G.
Starodubova, Antonina V.
Popkova, Tatyana V.
Orekhov, Alexander N.
The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title_full The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title_fullStr The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title_full_unstemmed The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title_short The Role of Mitochondria-Derived Peptides in Cardiovascular Diseases and Their Potential as Therapeutic Targets
title_sort role of mitochondria-derived peptides in cardiovascular diseases and their potential as therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396025/
https://www.ncbi.nlm.nih.gov/pubmed/34445477
http://dx.doi.org/10.3390/ijms22168770
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