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Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones

Fluoroquinolones are associated with an increased risk of Clostridioides difficile infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on develop...

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Autores principales: Sheffield, Mary E., Jones, Bruce M., Terrell, Blake, Wagner, Jamie L., Bland, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396168/
https://www.ncbi.nlm.nih.gov/pubmed/34449745
http://dx.doi.org/10.3390/pharmacy9030141
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author Sheffield, Mary E.
Jones, Bruce M.
Terrell, Blake
Wagner, Jamie L.
Bland, Christopher M.
author_facet Sheffield, Mary E.
Jones, Bruce M.
Terrell, Blake
Wagner, Jamie L.
Bland, Christopher M.
author_sort Sheffield, Mary E.
collection PubMed
description Fluoroquinolones are associated with an increased risk of Clostridioides difficile infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on development of primary CDI among hospitalized patients receiving fluoroquinolones. A retrospective cohort was evaluated that consisted of two groups of 100 patients each, admitted August 2018 through August 2020 that received ≥3 days of definitive monotherapy with levofloxacin or ciprofloxacin within 72 h of admission. Primary outcome was incidence of CDI. Secondary outcomes included rates of C. difficile diagnostic stool testing, additional infectious diagnostic testing, and non-CDI related gastrointestinal side effects. Patients on fluoroquinolones who received probiotics had a non-statistically significantly lower incidence in overall cases of CDI compared to those who did not receive probiotics (0% vs. 3%, p = 0.246). Patients who received probiotics had statistically significantly fewer C. difficile diagnostic stool tests performed (4% vs. 16%, p = 0.005) and fewer additional infectious diagnostic testing performed (4% vs. 10%, p = 0.096), respectively. Further research is warranted to optimize and standardize probiotic prescribing in high-risk patients.
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spelling pubmed-83961682021-08-28 Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones Sheffield, Mary E. Jones, Bruce M. Terrell, Blake Wagner, Jamie L. Bland, Christopher M. Pharmacy (Basel) Article Fluoroquinolones are associated with an increased risk of Clostridioides difficile infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on development of primary CDI among hospitalized patients receiving fluoroquinolones. A retrospective cohort was evaluated that consisted of two groups of 100 patients each, admitted August 2018 through August 2020 that received ≥3 days of definitive monotherapy with levofloxacin or ciprofloxacin within 72 h of admission. Primary outcome was incidence of CDI. Secondary outcomes included rates of C. difficile diagnostic stool testing, additional infectious diagnostic testing, and non-CDI related gastrointestinal side effects. Patients on fluoroquinolones who received probiotics had a non-statistically significantly lower incidence in overall cases of CDI compared to those who did not receive probiotics (0% vs. 3%, p = 0.246). Patients who received probiotics had statistically significantly fewer C. difficile diagnostic stool tests performed (4% vs. 16%, p = 0.005) and fewer additional infectious diagnostic testing performed (4% vs. 10%, p = 0.096), respectively. Further research is warranted to optimize and standardize probiotic prescribing in high-risk patients. MDPI 2021-08-18 /pmc/articles/PMC8396168/ /pubmed/34449745 http://dx.doi.org/10.3390/pharmacy9030141 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sheffield, Mary E.
Jones, Bruce M.
Terrell, Blake
Wagner, Jamie L.
Bland, Christopher M.
Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title_full Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title_fullStr Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title_full_unstemmed Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title_short Influence of Probiotics on the Development of Clostridioides difficile Infection in Patients Receiving Fluoroquinolones
title_sort influence of probiotics on the development of clostridioides difficile infection in patients receiving fluoroquinolones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396168/
https://www.ncbi.nlm.nih.gov/pubmed/34449745
http://dx.doi.org/10.3390/pharmacy9030141
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