Cargando…
The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T
Blood Oxygen Level Dependent (BOLD) is a commonly-used MR imaging technique in studying brain function. The BOLD signal can be strongly affected by specific sequence parameters, especially in small field strengths. Previous small-scale studies have investigated the effect of TE on BOLD contrast. Thi...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396192/ https://www.ncbi.nlm.nih.gov/pubmed/34449739 http://dx.doi.org/10.3390/tomography7030030 |
_version_ | 1783744316101885952 |
---|---|
author | Boursianis, Themistoklis Kalaitzakis, Georgios Nikiforaki, Katerina Kosteletou, Emmanouela Antypa, Despina Gourzoulidis, George A. Karantanas, Apostolos Papadaki, Efrosini Simos, Panagiotis Maris, Thomas G. Marias, Kostas |
author_facet | Boursianis, Themistoklis Kalaitzakis, Georgios Nikiforaki, Katerina Kosteletou, Emmanouela Antypa, Despina Gourzoulidis, George A. Karantanas, Apostolos Papadaki, Efrosini Simos, Panagiotis Maris, Thomas G. Marias, Kostas |
author_sort | Boursianis, Themistoklis |
collection | PubMed |
description | Blood Oxygen Level Dependent (BOLD) is a commonly-used MR imaging technique in studying brain function. The BOLD signal can be strongly affected by specific sequence parameters, especially in small field strengths. Previous small-scale studies have investigated the effect of TE on BOLD contrast. This study evaluates the dependence of fMRI results on echo time (TE) during concurrent activation of the visual and motor cortex at 1.5 T in a larger sample of 21 healthy volunteers. The experiment was repeated using two different TE values (50 and 70 ms) in counterbalanced order. Furthermore, T2* measurements of the gray matter were performed. Results indicated that both peak beta value and number of voxels were significantly higher using TE = 70 than TE = 50 ms in primary motor, primary somatosensory and supplementary motor cortices (p < 0.007). In addition, the amplitude of activation in visual cortices and the dorsal premotor area was also higher using TE = 70 ms (p < 0.001). Gray matter T2* of the corresponding areas did not vary significantly. In conclusion, the optimal TE value (among the two studied) for visual and motor activity is 70 ms affecting both the amplitude and extent of regional hemodynamic activation. |
format | Online Article Text |
id | pubmed-8396192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83961922021-08-28 The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T Boursianis, Themistoklis Kalaitzakis, Georgios Nikiforaki, Katerina Kosteletou, Emmanouela Antypa, Despina Gourzoulidis, George A. Karantanas, Apostolos Papadaki, Efrosini Simos, Panagiotis Maris, Thomas G. Marias, Kostas Tomography Article Blood Oxygen Level Dependent (BOLD) is a commonly-used MR imaging technique in studying brain function. The BOLD signal can be strongly affected by specific sequence parameters, especially in small field strengths. Previous small-scale studies have investigated the effect of TE on BOLD contrast. This study evaluates the dependence of fMRI results on echo time (TE) during concurrent activation of the visual and motor cortex at 1.5 T in a larger sample of 21 healthy volunteers. The experiment was repeated using two different TE values (50 and 70 ms) in counterbalanced order. Furthermore, T2* measurements of the gray matter were performed. Results indicated that both peak beta value and number of voxels were significantly higher using TE = 70 than TE = 50 ms in primary motor, primary somatosensory and supplementary motor cortices (p < 0.007). In addition, the amplitude of activation in visual cortices and the dorsal premotor area was also higher using TE = 70 ms (p < 0.001). Gray matter T2* of the corresponding areas did not vary significantly. In conclusion, the optimal TE value (among the two studied) for visual and motor activity is 70 ms affecting both the amplitude and extent of regional hemodynamic activation. MDPI 2021-08-05 /pmc/articles/PMC8396192/ /pubmed/34449739 http://dx.doi.org/10.3390/tomography7030030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boursianis, Themistoklis Kalaitzakis, Georgios Nikiforaki, Katerina Kosteletou, Emmanouela Antypa, Despina Gourzoulidis, George A. Karantanas, Apostolos Papadaki, Efrosini Simos, Panagiotis Maris, Thomas G. Marias, Kostas The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title | The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title_full | The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title_fullStr | The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title_full_unstemmed | The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title_short | The Significance of Echo Time in fMRI BOLD Contrast: A Clinical Study during Motor and Visual Activation Tasks at 1.5 T |
title_sort | significance of echo time in fmri bold contrast: a clinical study during motor and visual activation tasks at 1.5 t |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396192/ https://www.ncbi.nlm.nih.gov/pubmed/34449739 http://dx.doi.org/10.3390/tomography7030030 |
work_keys_str_mv | AT boursianisthemistoklis thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT kalaitzakisgeorgios thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT nikiforakikaterina thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT kosteletouemmanouela thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT antypadespina thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT gourzoulidisgeorgea thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT karantanasapostolos thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT papadakiefrosini thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT simospanagiotis thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT maristhomasg thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT mariaskostas thesignificanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT boursianisthemistoklis significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT kalaitzakisgeorgios significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT nikiforakikaterina significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT kosteletouemmanouela significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT antypadespina significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT gourzoulidisgeorgea significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT karantanasapostolos significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT papadakiefrosini significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT simospanagiotis significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT maristhomasg significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t AT mariaskostas significanceofechotimeinfmriboldcontrastaclinicalstudyduringmotorandvisualactivationtasksat15t |