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Disruption of Cytosolic Folate Integrity Aggravates Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Modulates Metastatic Properties in Non-Small-Cell Lung Cancer Cells

Patients with advanced-stage non-small-cell lung cancer (NSCLC) are susceptible to malnutrition and develop folate deficiency (FD). We previously found that folate deprivation induces drug resistance in hepatocellular carcinoma; here, we assessed whether disrupted cytoplasmic folate metabolism could...

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Detalles Bibliográficos
Autores principales:	Shen, Po-Wen, Ho, Chun-Te, Hsiao, Shih-Hsin, Chou, Yu-Ting, Chang, Yi-Cheng, Liu, Jun-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396212/ https://www.ncbi.nlm.nih.gov/pubmed/34445544 http://dx.doi.org/10.3390/ijms22168838

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