Cargando…

LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration

Leucine-rich a-2-glycoprotein 1 (LRG1) is a candidate therapeutic target for treating the neovascular form of age-related macular degeneration (nvAMD). In this study we examined the expression of LRG1 in eyes of nvAMD patients. Choroidal neovascular membranes (CNVMs) from patients who underwent subm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mundo, Lucia, Tosi, Gian Marco, Lazzi, Stefano, Pertile, Grazia, Parolini, Barbara, Neri, Giovanni, Posarelli, Matteo, De Benedetto, Elena, Bacci, Tommaso, Silvestri, Ennio, Siciliano, Maria Chiara, Barbera, Stefano, Orlandini, Maurizio, Greenwood, John, Moss, Stephen E., Galvagni, Federico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396268/ https://www.ncbi.nlm.nih.gov/pubmed/34445590 http://dx.doi.org/10.3390/ijms22168879

Ejemplares similares

The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization
por: Tosi, Gian Marco, et al.
Publicado: (2020)

TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration
por: Tosi, Gian Marco, et al.
Publicado: (2018)

Publisher Correction: TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration
por: Tosi, Gian Marco, et al.
Publicado: (2018)

The Controversial Role of TGF-β in Neovascular Age-Related Macular Degeneration Pathogenesis
por: Tosi, Gian Marco, et al.
Publicado: (2018)

MicroRNA Expression in the Aqueous Humor of Patients with Diabetic Macular Edema
por: Grieco, Giuseppina Emanuela, et al.
Publicado: (2020)

LRG1: an emerging player in disease pathogenesis
por: Camilli, Carlotta, et al.
Publicado: (2022)

Intravitreal Brolucizumab for Neovascular Age-Related Macular Degeneration in a Vitrectomized Eye
por: Maggio, Emilia, et al.
Publicado: (2022)

LRG1 as a novel therapeutic target in eye disease
por: De Rossi, Giulia, et al.
Publicado: (2022)

Correction: LRG1 as a novel therapeutic target in eye disease
por: De Rossi, Giulia, et al.
Publicado: (2022)

CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells
por: Barbera, Stefano, et al.
Publicado: (2021)

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
por: Dritsoula, Athina, et al.
Publicado: (2022)

LRG1 promotes angiogenesis by modulating endothelial TGFß signalling
por: Wang, Xiaomeng, et al.
Publicado: (2013)

Publisher Correction: Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway
por: Dritsoula, Athina, et al.
Publicado: (2022)

The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration
por: Barbera, Stefano, et al.
Publicado: (2019)

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation
por: Yang, Jimin, et al.
Publicado: (2023)

Structural basis of human LRG1 recognition by Magacizumab, a humanized monoclonal antibody with therapeutic potential
por: Gutiérrez-Fernández, Javier, et al.
Publicado: (2022)

Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target
por: Javaid, Faiza, et al.
Publicado: (2021)

Retrobulbar triamcinolone for inflammatory choroidal neovascularization in pregnancy
por: Maggio, Emilia, et al.
Publicado: (2020)

Lamellar macular defects: are degenerative lamellar macular holes truly degenerative?
por: Pertile, Grazia, et al.
Publicado: (2023)

Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration
por: Lechner, Judith, et al.
Publicado: (2015)

Color Fundus Autofluorescence to Determine Activity of Macular Neovascularization in Age-Related Macular Degeneration
por: Vujosevic, Stela, et al.
Publicado: (2021)

Heat Shock Protein 90 Involvement in the Development of Idiopathic Epiretinal Membranes
por: Tosi, Gian Marco, et al.
Publicado: (2020)

Understanding LrgAB Regulation of Streptococcus mutans Metabolism
por: Ahn, Sang-Joon, et al.
Publicado: (2020)

Environmental Triggers of lrgA Expression in Streptococcus mutans
por: Ishkov, Ivan P., et al.
Publicado: (2020)

Macular neovascularization in eyes with pachydrusen
por: Teo, Kelvin Yi Chong, et al.
Publicado: (2021)

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis
por: Chen, Mei, et al.
Publicado: (2020)

InCASEOf scoring system for distinction between pachychoroid-associated macular neovascularization and neovascular age-related macular degeneration in patients older than 50 years
por: Cozzupoli, Grazia M., et al.
Publicado: (2022)

Modification of the Streptococcus mutans transcriptome by LrgAB and environmental stressors
por: Rice, Kelly C., et al.
Publicado: (2017)

Regulation of cid and lrg expression by CodY in Streptococcus mutans
por: Ahn, Sang‐Joon, et al.
Publicado: (2020)

LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation
por: Choi, Chan Hee J, et al.
Publicado: (2022)

LRG1 Associates with Iron Deficiency Anemia Markers in Adolescents
por: Alhammad, Rashed, et al.
Publicado: (2023)

STAT3 Activation in Circulating Monocytes Contributes to Neovascular Age-Related Macular Degeneration
por: Chen, M., et al.
Publicado: (2016)

Histology of neovascular myopic macular degeneration
por: Jonas, Shefali B., et al.
Publicado: (2021)

Evolution of macular atrophy in eyes with neovascular age-related macular degeneration compared to fellow non-neovascular eyes
por: Blazaki, Styliani, et al.
Publicado: (2023)

Macular neovascularization lesion type and vision outcomes in neovascular age-related macular degeneration: post hoc analysis of HARBOR
por: Freund, K. Bailey, et al.
Publicado: (2022)

Segmentation of macular neovascularization and leakage in fluorescein angiography images in neovascular age-related macular degeneration using deep learning
por: Holomcik, David, et al.
Publicado: (2022)

LRG1 expression indicates unfavorable clinical outcome in hepatocellular carcinoma
por: Wang, Chun-Hua, et al.
Publicado: (2015)

Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses
por: Ahn, Sang-Joon, et al.
Publicado: (2017)

Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence
por: Hoefsmit, Esmee P., et al.
Publicado: (2023)

Ranibizumab in neovascular age-related macular degeneration
por: Eng, Kenneth T, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_tubhh8rmu6jjmfu1vqud4upr9p