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Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers
Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396293/ https://www.ncbi.nlm.nih.gov/pubmed/34445521 http://dx.doi.org/10.3390/ijms22168817 |
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author | Zhang, Guangyan Yi, Hui Bao, Chenhui |
author_facet | Zhang, Guangyan Yi, Hui Bao, Chenhui |
author_sort | Zhang, Guangyan |
collection | PubMed |
description | Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers. |
format | Online Article Text |
id | pubmed-8396293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83962932021-08-28 Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers Zhang, Guangyan Yi, Hui Bao, Chenhui Int J Mol Sci Review Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers. MDPI 2021-08-16 /pmc/articles/PMC8396293/ /pubmed/34445521 http://dx.doi.org/10.3390/ijms22168817 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Guangyan Yi, Hui Bao, Chenhui Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title | Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title_full | Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title_fullStr | Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title_full_unstemmed | Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title_short | Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers |
title_sort | stimuli-responsive poly(aspartamide) derivatives and their applications as drug carriers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396293/ https://www.ncbi.nlm.nih.gov/pubmed/34445521 http://dx.doi.org/10.3390/ijms22168817 |
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