Cargando…

Pathogenic Mechanisms of Hypertrophic Cardiomyopathy beyond Sarcomere Dysfunction

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, affecting 1 in 500 people in the general population. Although characterized by asymmetric left ventricular hypertrophy, cardiomyocyte disarray, and cardiac fibrosis, HCM is in fact a highly complex disease with h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Chun, Chin, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396307/ https://www.ncbi.nlm.nih.gov/pubmed/34445638 http://dx.doi.org/10.3390/ijms22168933

Ejemplares similares

Multimodality Imaging in Sarcomeric Hypertrophic Cardiomyopathy: Get It Right…on Time
por: Galluzzo, Alessandro, et al.
Publicado: (2023)

Childhood Hypertrophic Cardiomyopathy: A Disease of the Cardiac Sarcomere
por: Norrish, Gabrielle, et al.
Publicado: (2021)

Penetrance of Hypertrophic Cardiomyopathy in Sarcomere Protein Mutation Carriers
por: Lorenzini, Massimiliano, et al.
Publicado: (2020)

Genetic and Molecular Mechanisms of Hypertrophic Cardiomyopathy
por: Chou, Chun, et al.
Publicado: (2023)

Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity
por: de Feria, Alejandro E, et al.
Publicado: (2021)

Comparative analysis of right ventricular strain in Fabry cardiomyopathy and sarcomeric hypertrophic cardiomyopathy
por: Meucci, Maria Chiara, et al.
Publicado: (2022)

Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy
por: Bottillo, Irene, et al.
Publicado: (2016)

Sarcomeric gene variants among Indians with hypertrophic cardiomyopathy: A scoping review
por: Koshy, Linda, et al.
Publicado: (2023)

Hypertrophic Cardiomyopathy in Children: Pathophysiology, Diagnosis, and Treatment of Non-sarcomeric Causes
por: Monda, Emanuele, et al.
Publicado: (2021)

A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations
por: Cohn, Rachel, et al.
Publicado: (2018)

Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy
por: Bailey, Kate E., et al.
Publicado: (2019)

Disruption of embryonic ROCK signaling reproduces the sarcomeric phenotype of hypertrophic cardiomyopathy
por: Bailey, Kate E., et al.
Publicado: (2020)

Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy
por: Joy, George, et al.
Publicado: (2023)

Novel Morphological Features on CMR for the Prediction of Pathogenic Sarcomere Gene Variants in Subjects Without Hypertrophic Cardiomyopathy
por: van der Velde, Nikki, et al.
Publicado: (2021)

Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy—The Graz Hypertrophic Cardiomyopathy Registry
por: Höller, Viktoria, et al.
Publicado: (2021)

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes
por: Walsh, Roddy, et al.
Publicado: (2017)

The Definition of Sarcomeric and Non-Sarcomeric Gene Mutations in Hypertrophic Cardiomyopathy Patients: A Multicenter Diagnostic Study Across Türkiye
por: Oktay, Veysel, et al.
Publicado: (2023)

Temporal Trend of Age at Diagnosis in Hypertrophic Cardiomyopathy: An Analysis of the International Sarcomeric Human Cardiomyopathy Registry
por: Canepa, Marco, et al.
Publicado: (2020)

Contribution of sarcomere gene mutations to left atrial function in patients with hypertrophic cardiomyopathy
por: Chung, Hyemoon, et al.
Publicado: (2021)

Effect of sarcomere and mitochondria-related mutations on myocardial fibrosis in patients with hypertrophic cardiomyopathy
por: Chung, Hyemoon, et al.
Publicado: (2021)

Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Analysis of the Serum Peptidomics Profile for Cats With Sarcomeric Gene Mutation and Hypertrophic Cardiomyopathy
por: Sukumolanan, Pratch, et al.
Publicado: (2021)

Preclinical alterations in cardiac energetics amongst sarcomere mutation carriers in hypertrophic cardiomyopathy
por: Lloyd, Rachael, et al.
Publicado: (2015)

Microvascular Dysfunction in Hypertrophic Cardiomyopathy
por: Pelliccia, Francesco, et al.
Publicado: (2022)

Regression of Left Ventricular Hypertrophy in a Case of Sarcomeric Hypertrophic Cardiomyopathy: An Unexpected Outcome
por: Cabrera Borrego, Eva, et al.
Publicado: (2020)

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights From the Sarcomeric Human Cardiomyopathy Registry (SHaRe)
por: Ho, Carolyn Y., et al.
Publicado: (2018)

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy
por: Toepfer, Christopher N., et al.
Publicado: (2020)

Prognostic significance of left atrial strain in sarcomere gene variant carriers without hypertrophic cardiomyopathy
por: Huurman, Roy, et al.
Publicado: (2022)

Sarcomere Dysfunction in Nemaline Myopathy
por: de Winter, Josine M., et al.
Publicado: (2017)

Proteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy
por: Garmany, Ramin, et al.
Publicado: (2023)

Left Atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy
por: Farhad, Hoshang, et al.
Publicado: (2017)

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus)
por: Messer, Andrew E., et al.
Publicado: (2017)

Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics
por: Tucholski, Trisha, et al.
Publicado: (2020)

Becker muscular dystrophy associated with sarcomeric hypertrophic cardiomyopathy in a paediatric patient: a case report
por: Dolader, Paola, et al.
Publicado: (2019)

Genetic advances in sarcomeric cardiomyopathies: state of the art
por: Ho, Carolyn Y., et al.
Publicado: (2015)

Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation
por: Clippinger, Sarah R., et al.
Publicado: (2021)

Left atrial remodeling and mechanical dysfunction in hypertrophic cardiomyopathy
por: Kim, Kyung-Jin, et al.
Publicado: (2016)

Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies
por: Tsukamoto, Osamu
Publicado: (2019)

Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathy
por: Regnier, Michael
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ulfa9ol83p4af6vqf2fk48obda