Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) performed by O-GlcNAc transferase (OGT) is a nutrient-responsive post-translational modification (PTM) via the hexosamine biosynthetic pathway (HBP). Various transcription factors (TFs) are O-GlcNAcylated, affecting their activities and significan...

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Detalles Bibliográficos
Autores principales: Kim, Myoung Jun, Kim, Hyuk Soon, Lee, Sangyong, Min, Keun Young, Choi, Wahn Soo, You, Jueng Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396330/
https://www.ncbi.nlm.nih.gov/pubmed/34445596
http://dx.doi.org/10.3390/ijms22168888

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