Cargando…

Mice Harboring a Non-Functional CILK1/ICK Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant CILK1/ICK

CILK1 (ciliogenesis associated kinase 1)/ICK (intestinal cell kinase) is a highly conserved protein kinase that regulates primary cilia structure and function. CILK1 mutations cause a wide spectrum of human diseases collectively called ciliopathies. While several CILK1 heterozygous variants have bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salvati, Kathryn A., Mason, Ashley J., Gailey, Casey D., Wang, Eric J., Fu, Zheng, Beenhakker, Mark P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396347/ https://www.ncbi.nlm.nih.gov/pubmed/34445580 http://dx.doi.org/10.3390/ijms22168875

Ejemplares similares

BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1
por: Satoda, Yuuki, et al.
Publicado: (2022)

Modulation of Primary Cilia by Alvocidib Inhibition of CILK1
por: Wang, Elena X., et al.
Publicado: (2022)

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy
por: Wang, Eric J., et al.
Publicado: (2020)

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis
por: Oh, Yoon Seon, et al.
Publicado: (2019)

Identification and functional analysis of the ICK gene family in maize
por: Xiao, Qianlin, et al.
Publicado: (2017)

Regulation of Cilium Length and Intraflagellar Transport by the RCK-Kinases ICK and MOK in Renal Epithelial Cells
por: Broekhuis, Joost R., et al.
Publicado: (2014)

A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome
por: Oud, Machteld M., et al.
Publicado: (2016)

Distinct Expression Patterns of ICK/MAK/MOK Protein Kinases in the Intestine Implicate Functional Diversity
por: Chen, Tufeng, et al.
Publicado: (2013)

New Insectotoxin from Tibellus Oblongus Spider Venom Presents Novel Adaptation of ICK Fold
por: Korolkova, Yuliya, et al.
Publicado: (2021)

Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
por: Ohta, Masataka, et al.
Publicado: (1990)

A Chemical Biology Approach to Probing the Folding Pathways of the Inhibitory Cystine Knot (ICK) Peptide ProTx-II
por: McCarthy, Stephen, et al.
Publicado: (2020)

Down-regulation of multiple CDK inhibitor ICK/KRP genes promotes cell proliferation, callus induction and plant regeneration in Arabidopsis
por: Cheng, Yan, et al.
Publicado: (2015)

Circumventing the “Ick” Factor: A Randomized Trial of the Effects of Omitting Affective Attitudes Questions to Increase Intention to Become an Organ Donor
por: Doherty, Sally, et al.
Publicado: (2017)

Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors
por: Kasheverov, Igor E., et al.
Publicado: (2022)

Cyclin-Dependent Kinase Inhibitor Gene TaICK1 acts as a Potential Contributor to Wheat Male Sterility induced by a Chemical Hybridizing Agent
por: Zhang, Lili, et al.
Publicado: (2020)

The Arabidopsis CDK inhibitor ICK3/KRP5 is rate limiting for primary root growth and promotes growth through cell elongation and endoreduplication
por: Wen, Bo, et al.
Publicado: (2013)

Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule
por: Cao, Ling, et al.
Publicado: (2018)

Characterization and Expression of the Gene Encoding En-MAPK1, an Intestinal Cell Kinase (ICK)-like Kinase Activated by the Autocrine Pheromone-Signaling Loop in the Polar Ciliate, Euplotes nobilii
por: Candelori, Annalisa, et al.
Publicado: (2013)

Astrocyte Receptor Rebirth
por: Salvati, Kathryn, et al.
Publicado: (2019)

Lost in Space: How a Single, Directionless Protein Can Cause So Much Mayhem
por: Salvati, Kathryn A., et al.
Publicado: (2020)

In vivo calcium imaging reveals disordered interictal network dynamics in epileptic stxbp1b zebrafish
por: Liu, Jing, et al.
Publicado: (2021)

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease
por: Gnjec, Anastazija, et al.
Publicado: (2008)

Non-Penetrance for Ocular Phenotype in Two Individuals Carrying Heterozygous Loss-of-Function ZEB1 Alleles
por: Dudakova, Lubica, et al.
Publicado: (2021)

LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation
por: Stieve, Bethany J., et al.
Publicado: (2023)

Genotypic and Phenotypic Characterization of Clinical Escherichia coli Sequence Type 405 Carrying IncN2 Plasmid Harboring bla(NDM-1)
por: Hao, Yingying, et al.
Publicado: (2019)

Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy
por: Chatron, Nicolas, et al.
Publicado: (2020)

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
por: Wijshake, Tobias, et al.
Publicado: (2012)

Emergence of Phytobacter diazotrophicus carrying an IncA/C(2) plasmid harboring bla(NDM-1) in Tokyo, Japan
por: Kubota, Hiroaki, et al.
Publicado: (2023)

Osimertinib in Combination with Bevacizumab Fails in Advanced Lung Adenocarcinoma Harboring EGFR T790M
por: Zhang, Xiaoying
Publicado: (2021)

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences
por: Spracklen, Cassandra N., et al.
Publicado: (2020)

Increased Risk of Clopidogrel-Induced Gastric Mucosal Erosion in Elderly Chinese Men Harboring the ABCB1 3435T Allele
por: Duan, Lei, et al.
Publicado: (2020)

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles
por: Law, Soi Cheng, et al.
Publicado: (2012)

Mice Carrying a Hypomorphic Evi1 Allele Are Embryonic Viable but Exhibit Severe Congenital Heart Defects
por: Bard-Chapeau, Emilie A., et al.
Publicado: (2014)

Aged mice ovaries harbor stem cells and germ cell nests but fail to form follicles
por: Sharma, Diksha, et al.
Publicado: (2022)

HLA Class II Alleles Susceptibility Markers of Type 1 Diabetes Fail to Specify Phenotypes of Ketosis-Prone Diabetes in Adult Tunisian Patients
por: Laadhar, Lilia, et al.
Publicado: (2011)

Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes
por: Larson, Jon S, et al.
Publicado: (2006)

Case Report: Clinical Features of a Chinese Boy With Epileptic Seizures and Intellectual Disabilities Who Carries a Truncated NUS1 Variant
por: Zhang, Pingli, et al.
Publicado: (2021)

An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele
por: Meuret, Cristiana J., et al.
Publicado: (2023)

Sequencing of bla(IMP)-Carrying IncN2 Plasmids, and Comparative Genomics of IncN2 Plasmids Harboring Class 1 Integrons
por: Jiang, Xiaoyuan, et al.
Publicado: (2017)

Correction: Aged mice ovaries harbor stem cells and germ cell nests but fail to form follicles
por: Sharma, Diksha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4peb8f9put0s8jvj5v980ndl04