Physiologic Mechanical Stress Directly Induces Bone Formation by Activating Glucose Transporter 1 (Glut 1) in Osteoblasts, Inducing Signaling via NAD+-Dependent Deacetylase (Sirtuin 1) and Runt-Related Transcription Factor 2 (Runx2)

Mechanical stress is an important factor affecting bone tissue homeostasis. We focused on the interactions among mechanical stress, glucose uptake via glucose transporter 1 (Glut1), and the cellular energy sensor sirtuin 1 (SIRT1) in osteoblast energy metabolism, since it has been recognized that SI...

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Detalles Bibliográficos
Autores principales: Somemura, Shu, Kumai, Takanori, Yatabe, Kanaka, Sasaki, Chizuko, Fujiya, Hiroto, Niki, Hisateru, Yudoh, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396442/
https://www.ncbi.nlm.nih.gov/pubmed/34445787
http://dx.doi.org/10.3390/ijms22169070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396442/
https://www.ncbi.nlm.nih.gov/pubmed/34445787
http://dx.doi.org/10.3390/ijms22169070

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