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Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review

Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could...

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Detalles Bibliográficos
Autores principales: Antony, Priya, Vijayan, Ranjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396489/
https://www.ncbi.nlm.nih.gov/pubmed/34445765
http://dx.doi.org/10.3390/ijms22169059
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author Antony, Priya
Vijayan, Ranjit
author_facet Antony, Priya
Vijayan, Ranjit
author_sort Antony, Priya
collection PubMed
description Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could significantly contribute to bringing this under control. Food-derived bioactive peptides and protein hydrolysates have been associated with a number health benefits. Several peptides with antidiabetic potential have been identified that could decrease blood glucose level, improve insulin uptake and inhibit key enzymes involved in the development and progression of diabetes. Dietary proteins, from a wide range of food, are rich sources of antidiabetic peptides. Thus, there are a number of benefits in studying peptides obtained from food sources to develop nutraceuticals. A deeper understanding of the underlying molecular mechanisms of these peptides will assist in the development of new peptide-based therapeutics. Despite this, a comprehensive analysis of the antidiabetic properties of bioactive peptides derived from various food sources is still lacking. Here, we review the recent literature on food-derived bioactive peptides possessing antidiabetic activity. The focus is on the effectiveness of these peptides as evidenced by in vitro and in vivo studies. Finally, we discuss future prospects of peptide-based drugs for the treatment of diabetes.
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spelling pubmed-83964892021-08-28 Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review Antony, Priya Vijayan, Ranjit Int J Mol Sci Review Diabetes mellitus is a major public health concern associated with high mortality and reduced life expectancy. The alarming rise in the prevalence of diabetes is linked to several factors including sedentary lifestyle and unhealthy diet. Nutritional intervention and increased physical activity could significantly contribute to bringing this under control. Food-derived bioactive peptides and protein hydrolysates have been associated with a number health benefits. Several peptides with antidiabetic potential have been identified that could decrease blood glucose level, improve insulin uptake and inhibit key enzymes involved in the development and progression of diabetes. Dietary proteins, from a wide range of food, are rich sources of antidiabetic peptides. Thus, there are a number of benefits in studying peptides obtained from food sources to develop nutraceuticals. A deeper understanding of the underlying molecular mechanisms of these peptides will assist in the development of new peptide-based therapeutics. Despite this, a comprehensive analysis of the antidiabetic properties of bioactive peptides derived from various food sources is still lacking. Here, we review the recent literature on food-derived bioactive peptides possessing antidiabetic activity. The focus is on the effectiveness of these peptides as evidenced by in vitro and in vivo studies. Finally, we discuss future prospects of peptide-based drugs for the treatment of diabetes. MDPI 2021-08-22 /pmc/articles/PMC8396489/ /pubmed/34445765 http://dx.doi.org/10.3390/ijms22169059 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Antony, Priya
Vijayan, Ranjit
Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title_full Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title_fullStr Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title_full_unstemmed Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title_short Bioactive Peptides as Potential Nutraceuticals for Diabetes Therapy: A Comprehensive Review
title_sort bioactive peptides as potential nutraceuticals for diabetes therapy: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396489/
https://www.ncbi.nlm.nih.gov/pubmed/34445765
http://dx.doi.org/10.3390/ijms22169059
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