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Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so...

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Autores principales: Lisini, Daniela, Lettieri, Sara, Nava, Sara, Accordino, Giulia, Frigerio, Simona, Bortolotto, Chandra, Lancia, Andrea, Filippi, Andrea Riccardo, Agustoni, Francesco, Pandolfi, Laura, Piloni, Davide, Comoli, Patrizia, Corsico, Angelo Guido, Stella, Giulia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396500/
https://www.ncbi.nlm.nih.gov/pubmed/34445720
http://dx.doi.org/10.3390/ijms22169014
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author Lisini, Daniela
Lettieri, Sara
Nava, Sara
Accordino, Giulia
Frigerio, Simona
Bortolotto, Chandra
Lancia, Andrea
Filippi, Andrea Riccardo
Agustoni, Francesco
Pandolfi, Laura
Piloni, Davide
Comoli, Patrizia
Corsico, Angelo Guido
Stella, Giulia Maria
author_facet Lisini, Daniela
Lettieri, Sara
Nava, Sara
Accordino, Giulia
Frigerio, Simona
Bortolotto, Chandra
Lancia, Andrea
Filippi, Andrea Riccardo
Agustoni, Francesco
Pandolfi, Laura
Piloni, Davide
Comoli, Patrizia
Corsico, Angelo Guido
Stella, Giulia Maria
author_sort Lisini, Daniela
collection PubMed
description Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so far in the MPM. Combination immunotherapy might achieve better results over chemotherapy alone, but there is still a need for more effective therapeutic approaches. Based on the peculiar disease features of MPM, several strategies for local therapeutic delivery have been developed over the past years. The common rationale of these approaches is: (i) to reduce the risk of drug inactivation before reaching the target tumor cells; (ii) to increase the concentration of active drugs in the tumor micro-environment and their bioavailability; (iii) to reduce toxic effects on normal, non-transformed cells, because of much lower drug doses than those used for systemic chemotherapy. The complex interactions between drugs and the local immune-inflammatory micro-environment modulate the subsequent clinical response. In this perspective, the main interest is currently addressed to the development of local drug delivery platforms, both cell therapy and engineered nanotools. We here propose a review aimed at deep investigation of the biologic effects of the current local therapies for MPM, including cell therapies, and the mechanisms of interaction with the tumor micro-environment.
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spelling pubmed-83965002021-08-28 Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach Lisini, Daniela Lettieri, Sara Nava, Sara Accordino, Giulia Frigerio, Simona Bortolotto, Chandra Lancia, Andrea Filippi, Andrea Riccardo Agustoni, Francesco Pandolfi, Laura Piloni, Davide Comoli, Patrizia Corsico, Angelo Guido Stella, Giulia Maria Int J Mol Sci Review Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so far in the MPM. Combination immunotherapy might achieve better results over chemotherapy alone, but there is still a need for more effective therapeutic approaches. Based on the peculiar disease features of MPM, several strategies for local therapeutic delivery have been developed over the past years. The common rationale of these approaches is: (i) to reduce the risk of drug inactivation before reaching the target tumor cells; (ii) to increase the concentration of active drugs in the tumor micro-environment and their bioavailability; (iii) to reduce toxic effects on normal, non-transformed cells, because of much lower drug doses than those used for systemic chemotherapy. The complex interactions between drugs and the local immune-inflammatory micro-environment modulate the subsequent clinical response. In this perspective, the main interest is currently addressed to the development of local drug delivery platforms, both cell therapy and engineered nanotools. We here propose a review aimed at deep investigation of the biologic effects of the current local therapies for MPM, including cell therapies, and the mechanisms of interaction with the tumor micro-environment. MDPI 2021-08-20 /pmc/articles/PMC8396500/ /pubmed/34445720 http://dx.doi.org/10.3390/ijms22169014 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lisini, Daniela
Lettieri, Sara
Nava, Sara
Accordino, Giulia
Frigerio, Simona
Bortolotto, Chandra
Lancia, Andrea
Filippi, Andrea Riccardo
Agustoni, Francesco
Pandolfi, Laura
Piloni, Davide
Comoli, Patrizia
Corsico, Angelo Guido
Stella, Giulia Maria
Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title_full Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title_fullStr Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title_full_unstemmed Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title_short Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach
title_sort local therapies and modulation of tumor surrounding stroma in malignant pleural mesothelioma: a translational approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396500/
https://www.ncbi.nlm.nih.gov/pubmed/34445720
http://dx.doi.org/10.3390/ijms22169014
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