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Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review
In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to conduct a systematic literature review on the c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396505/ https://www.ncbi.nlm.nih.gov/pubmed/34445713 http://dx.doi.org/10.3390/ijms22169004 |
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author | Emmanuel, Thomas Mistegård, Josephine Bregnhøj, Anne Johansen, Claus Iversen, Lars |
author_facet | Emmanuel, Thomas Mistegård, Josephine Bregnhøj, Anne Johansen, Claus Iversen, Lars |
author_sort | Emmanuel, Thomas |
collection | PubMed |
description | In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to conduct a systematic literature review on the current understanding of the role of TRMs in skin diseases and identify gaps as well as future research paths. EMBASE, PubMed, SCOPUS, Web of Science, Clinicaltrials.gov and WHO Trials Registry were searched systematically for relevant studies from their inception to October 2020. Included studies were reviewed independently by two authors. This study was conducted in accordance with the PRISMA-S guidelines. This protocol was registered with the PROSPERO database (ref: CRD42020206416). We identified 96 studies meeting the inclusion criteria. TRMs have mostly been investigated in murine skin and in relation to infectious skin diseases. Pathogenic TRMs have been characterized in various skin diseases including psoriasis, vitiligo and cutaneous T-cell lymphoma. Studies are needed to discover biomarkers that may delineate TRMs poised for pathogenic activity in skin diseases and establish to which extent TRMs are contingent on the local skin microenvironment. Additionally, future studies may investigate the effects of current treatments on the persistence of pathogenic TRMs in human skin. |
format | Online Article Text |
id | pubmed-8396505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83965052021-08-28 Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review Emmanuel, Thomas Mistegård, Josephine Bregnhøj, Anne Johansen, Claus Iversen, Lars Int J Mol Sci Review In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed to conduct a systematic literature review on the current understanding of the role of TRMs in skin diseases and identify gaps as well as future research paths. EMBASE, PubMed, SCOPUS, Web of Science, Clinicaltrials.gov and WHO Trials Registry were searched systematically for relevant studies from their inception to October 2020. Included studies were reviewed independently by two authors. This study was conducted in accordance with the PRISMA-S guidelines. This protocol was registered with the PROSPERO database (ref: CRD42020206416). We identified 96 studies meeting the inclusion criteria. TRMs have mostly been investigated in murine skin and in relation to infectious skin diseases. Pathogenic TRMs have been characterized in various skin diseases including psoriasis, vitiligo and cutaneous T-cell lymphoma. Studies are needed to discover biomarkers that may delineate TRMs poised for pathogenic activity in skin diseases and establish to which extent TRMs are contingent on the local skin microenvironment. Additionally, future studies may investigate the effects of current treatments on the persistence of pathogenic TRMs in human skin. MDPI 2021-08-20 /pmc/articles/PMC8396505/ /pubmed/34445713 http://dx.doi.org/10.3390/ijms22169004 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Emmanuel, Thomas Mistegård, Josephine Bregnhøj, Anne Johansen, Claus Iversen, Lars Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title | Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title_full | Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title_fullStr | Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title_full_unstemmed | Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title_short | Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review |
title_sort | tissue-resident memory t cells in skin diseases: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396505/ https://www.ncbi.nlm.nih.gov/pubmed/34445713 http://dx.doi.org/10.3390/ijms22169004 |
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