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Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache
Chronic headache is a topical problem of neurology, psychiatry and general practice. The medication-overuse headache (MOH) is one of the leading pathologies in the structure of chronic headache. However, early diagnosis of the MOH is challenging. We analyzed potential proteomic biomarkers of serum a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396559/ https://www.ncbi.nlm.nih.gov/pubmed/34445731 http://dx.doi.org/10.3390/ijms22169024 |
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author | Shnayder, Natalia A. Sharavii, Victoria B. Petrova, Marina M. Moskaleva, Polina V. Pozhilenkova, Elena A. Kaskaeva, Darya S. Tutynina, Olga. V. Popova, Tatiana E. Garganeeva, Natalia P. Nasyrova, Regina F. |
author_facet | Shnayder, Natalia A. Sharavii, Victoria B. Petrova, Marina M. Moskaleva, Polina V. Pozhilenkova, Elena A. Kaskaeva, Darya S. Tutynina, Olga. V. Popova, Tatiana E. Garganeeva, Natalia P. Nasyrova, Regina F. |
author_sort | Shnayder, Natalia A. |
collection | PubMed |
description | Chronic headache is a topical problem of neurology, psychiatry and general practice. The medication-overuse headache (MOH) is one of the leading pathologies in the structure of chronic headache. However, early diagnosis of the MOH is challenging. We analyzed potential proteomic biomarkers of serum and urine in patients with MOH. Methods: We searched PubMed, Springer, Scopus, Web of Science, ClinicalKey, and Google Scholar databases for English publications over the past 10 years using keywords and their combinations. Results: We found and analyzed seven studies that met the search criteria for the purpose of the review, including 24 serum proteomic biomarkers and 25 urine proteomic biomarkers of MOH. Moreover, the candidate genes and locus of the studied serum (vitamin D-binding protein, lipocalin-type prostaglandin D2 synthase, apolipoprotein E, etc.) and urine proteomic biomarkers (uromodulin, alpha-1-microglobulin, zinc-alpha-2-glycoprotein, etc.) of MOH are presented in this review. Conclusions: The serum and urine proteomic biomarkers of MOH can potentially help with the identification of patients with MOH development. Due to the relevance of the problem, the authors believe that further investigation of the MOH proteomic biomarkers in different ethnic and racial groups of patients with primary headache is necessary. In addition, it is important to investigate whether medications of different drug classes influence the levels of serum and urine proteomic biomarkers. |
format | Online Article Text |
id | pubmed-8396559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83965592021-08-28 Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache Shnayder, Natalia A. Sharavii, Victoria B. Petrova, Marina M. Moskaleva, Polina V. Pozhilenkova, Elena A. Kaskaeva, Darya S. Tutynina, Olga. V. Popova, Tatiana E. Garganeeva, Natalia P. Nasyrova, Regina F. Int J Mol Sci Review Chronic headache is a topical problem of neurology, psychiatry and general practice. The medication-overuse headache (MOH) is one of the leading pathologies in the structure of chronic headache. However, early diagnosis of the MOH is challenging. We analyzed potential proteomic biomarkers of serum and urine in patients with MOH. Methods: We searched PubMed, Springer, Scopus, Web of Science, ClinicalKey, and Google Scholar databases for English publications over the past 10 years using keywords and their combinations. Results: We found and analyzed seven studies that met the search criteria for the purpose of the review, including 24 serum proteomic biomarkers and 25 urine proteomic biomarkers of MOH. Moreover, the candidate genes and locus of the studied serum (vitamin D-binding protein, lipocalin-type prostaglandin D2 synthase, apolipoprotein E, etc.) and urine proteomic biomarkers (uromodulin, alpha-1-microglobulin, zinc-alpha-2-glycoprotein, etc.) of MOH are presented in this review. Conclusions: The serum and urine proteomic biomarkers of MOH can potentially help with the identification of patients with MOH development. Due to the relevance of the problem, the authors believe that further investigation of the MOH proteomic biomarkers in different ethnic and racial groups of patients with primary headache is necessary. In addition, it is important to investigate whether medications of different drug classes influence the levels of serum and urine proteomic biomarkers. MDPI 2021-08-21 /pmc/articles/PMC8396559/ /pubmed/34445731 http://dx.doi.org/10.3390/ijms22169024 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shnayder, Natalia A. Sharavii, Victoria B. Petrova, Marina M. Moskaleva, Polina V. Pozhilenkova, Elena A. Kaskaeva, Darya S. Tutynina, Olga. V. Popova, Tatiana E. Garganeeva, Natalia P. Nasyrova, Regina F. Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title | Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title_full | Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title_fullStr | Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title_full_unstemmed | Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title_short | Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache |
title_sort | candidate genes and proteomic biomarkers of serum and urine in medication-overuse headache |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396559/ https://www.ncbi.nlm.nih.gov/pubmed/34445731 http://dx.doi.org/10.3390/ijms22169024 |
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