Cargando…

Multiomic Approaches to Uncover the Complexities of Dystrophin-Associated Cardiomyopathy

Despite major progress in treating skeletal muscle disease associated with dystrophinopathies, cardiomyopathy is emerging as a major cause of death in people carrying dystrophin gene mutations that remain without a targeted cure even with new treatment directions and advances in modelling abilities....

Descripción completa

Detalles Bibliográficos
Autores principales:	Gowran, Aoife, Brioschi, Maura, Rovina, Davide, Chiesa, Mattia, Piacentini, Luca, Mallia, Sara, Banfi, Cristina, Pompilio, Giulio, Santoro, Rosaria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396646/ https://www.ncbi.nlm.nih.gov/pubmed/34445659 http://dx.doi.org/10.3390/ijms22168954

Ejemplares similares

“Betwixt Mine Eye and Heart a League Is Took”: The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy
por: Rovina, Davide, et al.
Publicado: (2020)

Dystrophin Cardiomyopathies: Clinical Management, Molecular Pathogenesis and Evolution towards Precision Medicine
por: D’Amario, Domenico, et al.
Publicado: (2018)

The Endocannabinoid System and Cannabidiol: Past, Present, and Prospective for Cardiovascular Diseases
por: Rabino, Martina, et al.
Publicado: (2021)

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
por: Santoro, Rosaria, et al.
Publicado: (2019)

Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

Generation of the Becker muscular dystrophy patient derived induced pluripotent stem cell line carrying the DMD splicing mutation c.1705-8 T>C.
por: Rovina, Davide, et al.
Publicado: (2020)

Corrigendum: Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: the impact of full-length dystrophin deficiency
por: Pioner, Josè Manuel, et al.
Publicado: (2023)

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells
por: Gowran, Aoife, et al.
Publicado: (2016)

Multiomic characterization of disease progression in mice lacking dystrophin
por: Signorelli, Mirko, et al.
Publicado: (2023)

Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype
por: Soussi, Salwa, et al.
Publicado: (2023)

IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype
por: Soussi, Salwa, et al.
Publicado: (2023)

Multiomics Analysis of Transcriptome, Epigenome, and Genome Uncovers Putative Mechanisms for Dilated Cardiomyopathy
por: Liu, Li, et al.
Publicado: (2021)

Platelets in Healthy and Disease States: From Biomarkers Discovery to Drug Targets Identification by Proteomics
por: Gianazza, Erica, et al.
Publicado: (2020)

Multiplexed MRM-Based Proteomics Identified Multiple Biomarkers of Disease Severity in Human Heart Failure
por: Brioschi, Maura, et al.
Publicado: (2021)

Proteomics of Extracellular Vesicles: Update on Their Composition, Biological Roles and Potential Use as Diagnostic Tools in Atherosclerotic Cardiovascular Diseases
por: Mallia, Alice, et al.
Publicado: (2020)

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
por: Lippi, Melania, et al.
Publicado: (2022)

Prenylcysteine Oxidase 1 Is a Key Regulator of Adipogenesis
por: Banfi, Cristina, et al.
Publicado: (2023)

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies
por: Rabino, Martina, et al.
Publicado: (2023)

S-Thiolation Targets Albumin in Heart Failure
por: Brioschi, Maura, et al.
Publicado: (2020)

Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
por: Rabino, Martina, et al.
Publicado: (2023)

Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice
por: Parchen, Candace M, et al.
Publicado: (2009)

Multiomics uncovers developing immunological lineages in human [Image: see text]
por: Stephenson, Emily, et al.
Publicado: (2021)

Immature Circulating SP-B, Bound to HDL, Represents an Early Sign of Smoke-Induced Pathophysiological Alterations
por: Banfi, Cristina, et al.
Publicado: (2021)

Lipoxidation in cardiovascular diseases
por: Gianazza, Erica, et al.
Publicado: (2019)

Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin‐Deficient Hearts
por: Hammers, David W., et al.
Publicado: (2016)

Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy
por: Rodriguez-Gonzalez, Moises, et al.
Publicado: (2020)

Patient-specific primary and pluripotent stem cell-derived stromal cells recapitulate key aspects of arrhythmogenic cardiomyopathy
por: Maione, Angela Serena, et al.
Publicado: (2023)

Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells
por: Pontremoli, Marta, et al.
Publicado: (2018)

The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells
por: Banfi, Cristina, et al.
Publicado: (2022)

Pharmacometabolomics for the Study of Lipid-Lowering Therapies: Opportunities and Challenges
por: Gianazza, Erica, et al.
Publicado: (2023)

Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile
por: Stadiotti, Ilaria, et al.
Publicado: (2020)

Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy
por: Holland, Ashling, et al.
Publicado: (2014)

The absence of dystrophin brain isoform expression in healthy human heart ventricles explains the pathogenesis of 5' X-linked dilated cardiomyopathy
por: Neri, Marcella, et al.
Publicado: (2012)

Impact of Sacubitril/Valsartan on Circulating microRNA in Patients with Heart Failure
por: Brioschi, Maura, et al.
Publicado: (2023)

Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology
por: Tangeman, Jared A, et al.
Publicado: (2023)

Syngeneic Cardiac and Bone Marrow Stromal Cells Display Tissue-Specific microRNA Signatures and microRNA Subsets Restricted to Diverse Differentiation Processes
por: Meraviglia, Viviana, et al.
Publicado: (2014)

Sex-dependent differences in the secretome of human endothelial cells
por: Cattaneo, Maria Grazia, et al.
Publicado: (2021)

Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis
por: Banfi, Cristina, et al.
Publicado: (2022)

Gene Regulatory Network Analysis of Perivascular Adipose Tissue of Abdominal Aortic Aneurysm Identifies Master Regulators of Key Pathogenetic Pathways
por: Piacentini, Luca, et al.
Publicado: (2020)

Uncovering the true features of dystrophin gene rearrangement and improving the molecular diagnosis of Duchenne and Becker muscular dystrophies
por: Ling, Chao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8e3tsf7pgqqoj8aa68aff7lsba