Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection

BACKGROUND: The effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood. OBJECTIVES: We sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike protein on serologic responses to SARS-CoV...

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Detalles Bibliográficos
Autores principales: Lapp, Stacey A., Edara, Venkata Viswanadh, Lu, Austin, Lai, Lilin, Hussaini, Laila, Chahroudi, Ann, Anderson, Larry J., Suthar, Mehul S., Anderson, Evan J., Rostad, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396729/
https://www.ncbi.nlm.nih.gov/pubmed/34449792
http://dx.doi.org/10.1371/journal.pone.0256482

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