Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations

Pyruvate kinase (PK), encoded by the PKLR gene, is a key player in glycolysis controlling the integrity of erythrocytes. Due to Plasmodium selection, mutations for PK deficiency, which leads to hemolytic anemia, are associated with resistance to malaria in sub-Saharan Africa and with susceptibility...

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Autores principales: Bezerra, Ohanna Cavalcanti de Lima, Alvarado-Arnez, Lucia Elena, Mabunda, Nédio, Salomé, Graça, de Sousa, Amina, Kehdy, Fernanda de Souza Gomes, Sales-Marques, Carolinne, Manta, Fernanda Saloum de Neves, Andrade, Rafaela Mota, Ferreira, Laís Pereira, Leal-Calvo, Thyago, Cardoso, Cynthia Chester, Nunes, Kelly, Gouveia, Mateus H., Mbulaiteve, Sam M., Yeboah, Edward D., Hsing, Ann, Latini, Ana Carla Pereira, Leturiondo, André Luiz, Rodrigues, Fabíola da Costa, Noronha, Ariani Batista, Ferreira, Cynthia de Oliveira, Talhari, Carolina, Rêgo, Jamile Leão, Castellucci, Léa Cristina de Carvalho, Tarazona-Santos, Eduardo, de Carvalho, Elizeu Fagundes, Meyer, Diogo, Pinheiro, Roberta Olmo, Jani, Ilesh V., Pacheco, Antonio Guilherme, Moraes, Milton Ozório
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396769/
https://www.ncbi.nlm.nih.gov/pubmed/34449765
http://dx.doi.org/10.1371/journal.pntd.0009434

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