Cargando…

Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction

This non-comparative prospective case series was conducted to characterize the clinical impact of intense pulsed light (IPL)-based treatment in dry eyes associated to Meibomian gland dysfunction (MGD), defining the predicting factors for a successful outcome with this therapy in a large case series....

Descripción completa

Detalles Bibliográficos
Autores principales: Iradier, María T., del Buey, María Ángeles, Peris-Martínez, Cristina, Cedano, Priscilla, Piñero, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396809/
https://www.ncbi.nlm.nih.gov/pubmed/34441869
http://dx.doi.org/10.3390/jcm10163573
_version_ 1783744459859558400
author Iradier, María T.
del Buey, María Ángeles
Peris-Martínez, Cristina
Cedano, Priscilla
Piñero, David P.
author_facet Iradier, María T.
del Buey, María Ángeles
Peris-Martínez, Cristina
Cedano, Priscilla
Piñero, David P.
author_sort Iradier, María T.
collection PubMed
description This non-comparative prospective case series was conducted to characterize the clinical impact of intense pulsed light (IPL)-based treatment in dry eyes associated to Meibomian gland dysfunction (MGD), defining the predicting factors for a successful outcome with this therapy in a large case series. A total of 390 eyes (195 patients, range: 23–93 years) received four sessions of Optima IPL system (Lumenis, Yokneam, Israel). Significant changes were observed in tear film osmolarity in both eyes (p < 0.001) and in meibum quality (p < 0.001), with more eyes showing clear or yellow secretions after therapy. Mean change in the ocular surface disease index (OSDI) was −8.61, ranging from −27.00 to 11.00. This change was significantly correlated with the baseline value of OSDI (r = −0.489, p < 0.001). The change in osmolarity correlated significantly with the baseline osmolarity in both eyes (right r = −0.636, left r = −0.620, p < 0.001). A linear predicting model of the change in OSDI with therapy was obtained: change OSDI = 10.99 − 0.35 × OSDI − 1.03 × NIBUT(RE-LE) (mean non-invasive break up time of right and left eye) − 2.03 × Meibum quality grade (p = 0.001; R(2): 0.325). In conclusion, the improvement in symptomatology achieved with an IPL-based therapy can be predicted at baseline using a linear model considering the level of MGD and the magnitude of OSDI and NIBUT (non-invasive break-up time).
format Online
Article
Text
id pubmed-8396809
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83968092021-08-28 Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction Iradier, María T. del Buey, María Ángeles Peris-Martínez, Cristina Cedano, Priscilla Piñero, David P. J Clin Med Article This non-comparative prospective case series was conducted to characterize the clinical impact of intense pulsed light (IPL)-based treatment in dry eyes associated to Meibomian gland dysfunction (MGD), defining the predicting factors for a successful outcome with this therapy in a large case series. A total of 390 eyes (195 patients, range: 23–93 years) received four sessions of Optima IPL system (Lumenis, Yokneam, Israel). Significant changes were observed in tear film osmolarity in both eyes (p < 0.001) and in meibum quality (p < 0.001), with more eyes showing clear or yellow secretions after therapy. Mean change in the ocular surface disease index (OSDI) was −8.61, ranging from −27.00 to 11.00. This change was significantly correlated with the baseline value of OSDI (r = −0.489, p < 0.001). The change in osmolarity correlated significantly with the baseline osmolarity in both eyes (right r = −0.636, left r = −0.620, p < 0.001). A linear predicting model of the change in OSDI with therapy was obtained: change OSDI = 10.99 − 0.35 × OSDI − 1.03 × NIBUT(RE-LE) (mean non-invasive break up time of right and left eye) − 2.03 × Meibum quality grade (p = 0.001; R(2): 0.325). In conclusion, the improvement in symptomatology achieved with an IPL-based therapy can be predicted at baseline using a linear model considering the level of MGD and the magnitude of OSDI and NIBUT (non-invasive break-up time). MDPI 2021-08-13 /pmc/articles/PMC8396809/ /pubmed/34441869 http://dx.doi.org/10.3390/jcm10163573 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iradier, María T.
del Buey, María Ángeles
Peris-Martínez, Cristina
Cedano, Priscilla
Piñero, David P.
Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title_full Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title_fullStr Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title_full_unstemmed Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title_short Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
title_sort characterization and prediction of the clinical outcome of intense pulsed light-based treatment in dry eye associated to meibomian gland dysfunction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396809/
https://www.ncbi.nlm.nih.gov/pubmed/34441869
http://dx.doi.org/10.3390/jcm10163573
work_keys_str_mv AT iradiermariat characterizationandpredictionoftheclinicaloutcomeofintensepulsedlightbasedtreatmentindryeyeassociatedtomeibomianglanddysfunction
AT delbueymariaangeles characterizationandpredictionoftheclinicaloutcomeofintensepulsedlightbasedtreatmentindryeyeassociatedtomeibomianglanddysfunction
AT perismartinezcristina characterizationandpredictionoftheclinicaloutcomeofintensepulsedlightbasedtreatmentindryeyeassociatedtomeibomianglanddysfunction
AT cedanopriscilla characterizationandpredictionoftheclinicaloutcomeofintensepulsedlightbasedtreatmentindryeyeassociatedtomeibomianglanddysfunction
AT pinerodavidp characterizationandpredictionoftheclinicaloutcomeofintensepulsedlightbasedtreatmentindryeyeassociatedtomeibomianglanddysfunction