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Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries
In Prader–Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396837/ https://www.ncbi.nlm.nih.gov/pubmed/34441851 http://dx.doi.org/10.3390/jcm10163555 |
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author | Coupaye, Muriel Pellikaan, Karlijn Goldstone, Anthony P. Crinò, Antonino Grugni, Graziano Markovic, Tania P. Høybye, Charlotte Caixàs, Assumpta Mosbah, Helena De Graaff, Laura C. G. Tauber, Maithé Poitou, Christine |
author_facet | Coupaye, Muriel Pellikaan, Karlijn Goldstone, Anthony P. Crinò, Antonino Grugni, Graziano Markovic, Tania P. Høybye, Charlotte Caixàs, Assumpta Mosbah, Helena De Graaff, Laura C. G. Tauber, Maithé Poitou, Christine |
author_sort | Coupaye, Muriel |
collection | PubMed |
description | In Prader–Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely been reported. Our aim was to describe the prevalence and severity of hyponatremia in PWS. In October 2020, we performed a retrospective study based on the medical records of a large cohort of children and adults with PWS from seven countries. Among 1326 patients (68% adults), 34 (2.6%) had at least one episode of mild or moderate hyponatremia (125 ≤ Na < 135 mmol/L). The causes of non-severe hyponatremia were often multi-factorial, including psychotropic medication in 32%, EFI in 24% and hyperglycemia in 12%. No obvious cause was found in 29%. Seven (0.5%) adults experienced severe hyponatremia (Na < 125 mmol/L). Among these, five recovered completely, but two died. The causes of severe hyponatremia were desmopressin treatment for nocturnal enuresis (n = 2), EFI (n = 2), adrenal insufficiency (n = 1), diuretic treatment (n = 1) and unknown (n = 1). In conclusion, severe hyponatremia was very rare but potentially fatal in PWS. Desmopressin treatment for nocturnal enuresis should be avoided. Enquiring about EFI and monitoring serum sodium should be included in the routine follow-ups of patients with PWS. |
format | Online Article Text |
id | pubmed-8396837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83968372021-08-28 Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries Coupaye, Muriel Pellikaan, Karlijn Goldstone, Anthony P. Crinò, Antonino Grugni, Graziano Markovic, Tania P. Høybye, Charlotte Caixàs, Assumpta Mosbah, Helena De Graaff, Laura C. G. Tauber, Maithé Poitou, Christine J Clin Med Article In Prader–Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely been reported. Our aim was to describe the prevalence and severity of hyponatremia in PWS. In October 2020, we performed a retrospective study based on the medical records of a large cohort of children and adults with PWS from seven countries. Among 1326 patients (68% adults), 34 (2.6%) had at least one episode of mild or moderate hyponatremia (125 ≤ Na < 135 mmol/L). The causes of non-severe hyponatremia were often multi-factorial, including psychotropic medication in 32%, EFI in 24% and hyperglycemia in 12%. No obvious cause was found in 29%. Seven (0.5%) adults experienced severe hyponatremia (Na < 125 mmol/L). Among these, five recovered completely, but two died. The causes of severe hyponatremia were desmopressin treatment for nocturnal enuresis (n = 2), EFI (n = 2), adrenal insufficiency (n = 1), diuretic treatment (n = 1) and unknown (n = 1). In conclusion, severe hyponatremia was very rare but potentially fatal in PWS. Desmopressin treatment for nocturnal enuresis should be avoided. Enquiring about EFI and monitoring serum sodium should be included in the routine follow-ups of patients with PWS. MDPI 2021-08-12 /pmc/articles/PMC8396837/ /pubmed/34441851 http://dx.doi.org/10.3390/jcm10163555 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coupaye, Muriel Pellikaan, Karlijn Goldstone, Anthony P. Crinò, Antonino Grugni, Graziano Markovic, Tania P. Høybye, Charlotte Caixàs, Assumpta Mosbah, Helena De Graaff, Laura C. G. Tauber, Maithé Poitou, Christine Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title | Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title_full | Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title_fullStr | Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title_full_unstemmed | Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title_short | Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
title_sort | hyponatremia in children and adults with prader–willi syndrome: a survey involving seven countries |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396837/ https://www.ncbi.nlm.nih.gov/pubmed/34441851 http://dx.doi.org/10.3390/jcm10163555 |
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