Cargando…
Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss
The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of the present study was to evaluate thyroid hormone replacement dose in morbidly obese hypo...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396870/ https://www.ncbi.nlm.nih.gov/pubmed/34441981 http://dx.doi.org/10.3390/jcm10163685 |
_version_ | 1783744474414841856 |
---|---|
author | Juiz-Valiña, Paula Cordido, María Outeiriño-Blanco, Elena Pértega, Sonia Urones, Paula García-Brao, María Jesús Mena, Enrique Pena-Bello, Lara Sangiao-Alvarellos, Susana Cordido, Fernando |
author_facet | Juiz-Valiña, Paula Cordido, María Outeiriño-Blanco, Elena Pértega, Sonia Urones, Paula García-Brao, María Jesús Mena, Enrique Pena-Bello, Lara Sangiao-Alvarellos, Susana Cordido, Fernando |
author_sort | Juiz-Valiña, Paula |
collection | PubMed |
description | The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of the present study was to evaluate thyroid hormone replacement dose in morbidly obese hypothyroid patients after BS-induced weight loss. We explore the best type of measured or estimated body weight for LT4 dosing. We performed an observational study evaluating patients with morbid obesity and hypothyroidism who underwent BS. We included 48 patients (three men). In morbidly obese hypothyroid patients 12 months after BS-induced weight loss, the total LT4 dose or the LT4 dose/kg ideal body weight did not change, while there was a significant increase in LT4 dose/body surface area, LT4 dose/kg weight, LT4 dose/kg adjusted body weight, LT4 dose/kg body fat, and LT4 dose/kg lean body weight. There were no differences in LT4 dose and its variation between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). The present study strongly suggests that LT4 dosing in obese hypothyroid patients can be individually adapted more precisely if it is based on ideal body weight. |
format | Online Article Text |
id | pubmed-8396870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83968702021-08-28 Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss Juiz-Valiña, Paula Cordido, María Outeiriño-Blanco, Elena Pértega, Sonia Urones, Paula García-Brao, María Jesús Mena, Enrique Pena-Bello, Lara Sangiao-Alvarellos, Susana Cordido, Fernando J Clin Med Article The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of the present study was to evaluate thyroid hormone replacement dose in morbidly obese hypothyroid patients after BS-induced weight loss. We explore the best type of measured or estimated body weight for LT4 dosing. We performed an observational study evaluating patients with morbid obesity and hypothyroidism who underwent BS. We included 48 patients (three men). In morbidly obese hypothyroid patients 12 months after BS-induced weight loss, the total LT4 dose or the LT4 dose/kg ideal body weight did not change, while there was a significant increase in LT4 dose/body surface area, LT4 dose/kg weight, LT4 dose/kg adjusted body weight, LT4 dose/kg body fat, and LT4 dose/kg lean body weight. There were no differences in LT4 dose and its variation between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). The present study strongly suggests that LT4 dosing in obese hypothyroid patients can be individually adapted more precisely if it is based on ideal body weight. MDPI 2021-08-19 /pmc/articles/PMC8396870/ /pubmed/34441981 http://dx.doi.org/10.3390/jcm10163685 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Juiz-Valiña, Paula Cordido, María Outeiriño-Blanco, Elena Pértega, Sonia Urones, Paula García-Brao, María Jesús Mena, Enrique Pena-Bello, Lara Sangiao-Alvarellos, Susana Cordido, Fernando Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title | Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title_full | Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title_fullStr | Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title_full_unstemmed | Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title_short | Evaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight Loss |
title_sort | evaluation of thyroid hormone replacement dosing in morbidly obese hypothyroid patients after bariatric surgery-induced weight loss |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396870/ https://www.ncbi.nlm.nih.gov/pubmed/34441981 http://dx.doi.org/10.3390/jcm10163685 |
work_keys_str_mv | AT juizvalinapaula evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT cordidomaria evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT outeirinoblancoelena evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT pertegasonia evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT uronespaula evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT garciabraomariajesus evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT menaenrique evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT penabellolara evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT sangiaoalvarellossusana evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss AT cordidofernando evaluationofthyroidhormonereplacementdosinginmorbidlyobesehypothyroidpatientsafterbariatricsurgeryinducedweightloss |