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Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial
Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperative peripheral parenteral nutrition (PPN) support on...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396922/ https://www.ncbi.nlm.nih.gov/pubmed/34441942 http://dx.doi.org/10.3390/jcm10163647 |
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author | Sánchez-Guillén, Luis Soriano-Irigaray, Leticia López-Rodríguez-Arias, Francisco Barber, Xavier Murcia, Ana Alcaide, M José Aranaz-Ostáriz, Verónica Soler-Silva, Álvaro Navarro-Ruiz, Andrés Arroyo, Antonio |
author_facet | Sánchez-Guillén, Luis Soriano-Irigaray, Leticia López-Rodríguez-Arias, Francisco Barber, Xavier Murcia, Ana Alcaide, M José Aranaz-Ostáriz, Verónica Soler-Silva, Álvaro Navarro-Ruiz, Andrés Arroyo, Antonio |
author_sort | Sánchez-Guillén, Luis |
collection | PubMed |
description | Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperative peripheral parenteral nutrition (PPN) support on postoperative morbidity after colorectal cancer surgery within an enhanced recovery program. Methods: Patients were randomized into two groups: peripheral parenteral nutrition (PPN) (with Peri-Olimel N4-E) versus conventional fluid therapy (FT). Ninety-day postoperative complications, laboratory parameters, length of hospital stay, and compliance with the ERAS protocol were assessed. Results: A total of 158 patients were analysed. The overall 90-day complication rate was 38.6% (61 patients), and 24 patients had major complications (Clavien–Dindo III–V) (15.2%). In the multivariate analysis, the intervention (PPN vs. FC) showed a protective effect against postoperative complications (p = 0.0031, OR = 0.2 (CI: 0.08–0.87)). Following ordinal regression, PPN and early oral tolerance showed a protective effect, being less likely to develop complications or to move from minor to major complications. In patients with low compliance to ERAS during the first postoperative day, PPN showed a protective effect, preventing 28% of morbidity. Conclusions: Perioperative peripheral parenteral nutrition (PPN) support with Peri-Olimel N4-E in colorectal cancer surgery associated with early oral intake could reduce postoperative complications. |
format | Online Article Text |
id | pubmed-8396922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83969222021-08-28 Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial Sánchez-Guillén, Luis Soriano-Irigaray, Leticia López-Rodríguez-Arias, Francisco Barber, Xavier Murcia, Ana Alcaide, M José Aranaz-Ostáriz, Verónica Soler-Silva, Álvaro Navarro-Ruiz, Andrés Arroyo, Antonio J Clin Med Article Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperative peripheral parenteral nutrition (PPN) support on postoperative morbidity after colorectal cancer surgery within an enhanced recovery program. Methods: Patients were randomized into two groups: peripheral parenteral nutrition (PPN) (with Peri-Olimel N4-E) versus conventional fluid therapy (FT). Ninety-day postoperative complications, laboratory parameters, length of hospital stay, and compliance with the ERAS protocol were assessed. Results: A total of 158 patients were analysed. The overall 90-day complication rate was 38.6% (61 patients), and 24 patients had major complications (Clavien–Dindo III–V) (15.2%). In the multivariate analysis, the intervention (PPN vs. FC) showed a protective effect against postoperative complications (p = 0.0031, OR = 0.2 (CI: 0.08–0.87)). Following ordinal regression, PPN and early oral tolerance showed a protective effect, being less likely to develop complications or to move from minor to major complications. In patients with low compliance to ERAS during the first postoperative day, PPN showed a protective effect, preventing 28% of morbidity. Conclusions: Perioperative peripheral parenteral nutrition (PPN) support with Peri-Olimel N4-E in colorectal cancer surgery associated with early oral intake could reduce postoperative complications. MDPI 2021-08-18 /pmc/articles/PMC8396922/ /pubmed/34441942 http://dx.doi.org/10.3390/jcm10163647 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sánchez-Guillén, Luis Soriano-Irigaray, Leticia López-Rodríguez-Arias, Francisco Barber, Xavier Murcia, Ana Alcaide, M José Aranaz-Ostáriz, Verónica Soler-Silva, Álvaro Navarro-Ruiz, Andrés Arroyo, Antonio Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title | Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title_full | Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title_fullStr | Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title_full_unstemmed | Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title_short | Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial |
title_sort | effect of early peripheral parenteral nutrition support in an enhanced recovery program for colorectal cancer surgery: a randomized open trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396922/ https://www.ncbi.nlm.nih.gov/pubmed/34441942 http://dx.doi.org/10.3390/jcm10163647 |
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