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Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection

Although several biomarkers have shown correlation to prognosis in COVID-19 patients, their clinical value is limited because of lack of specificity, suboptimal sensibility or poor dynamic behavior. We hypothesized that circulating soluble ST2 (sST2) could be associated to a worse outcome in COVID-1...

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Autores principales: Sánchez-Marteles, Marta, Rubio-Gracia, Jorge, Peña-Fresneda, Natacha, Garcés-Horna, Vanesa, Gracia-Tello, Borja, Martínez-Lostao, Luis, Crespo-Aznárez, Silvia, Pérez-Calvo, Juan Ignacio, Giménez-López, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396994/
https://www.ncbi.nlm.nih.gov/pubmed/34441830
http://dx.doi.org/10.3390/jcm10163534
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author Sánchez-Marteles, Marta
Rubio-Gracia, Jorge
Peña-Fresneda, Natacha
Garcés-Horna, Vanesa
Gracia-Tello, Borja
Martínez-Lostao, Luis
Crespo-Aznárez, Silvia
Pérez-Calvo, Juan Ignacio
Giménez-López, Ignacio
author_facet Sánchez-Marteles, Marta
Rubio-Gracia, Jorge
Peña-Fresneda, Natacha
Garcés-Horna, Vanesa
Gracia-Tello, Borja
Martínez-Lostao, Luis
Crespo-Aznárez, Silvia
Pérez-Calvo, Juan Ignacio
Giménez-López, Ignacio
author_sort Sánchez-Marteles, Marta
collection PubMed
description Although several biomarkers have shown correlation to prognosis in COVID-19 patients, their clinical value is limited because of lack of specificity, suboptimal sensibility or poor dynamic behavior. We hypothesized that circulating soluble ST2 (sST2) could be associated to a worse outcome in COVID-19. In total, 152 patients admitted for confirmed COVID-19 were included in a prospective non-interventional, observational study. Blood samples were drawn at admission, 48–72 h later and at discharge. sST2 concentrations and routine blood laboratory were analyzed. Primary endpoints were admission at intensive care unit (ICU) and mortality. Median age was 57.5 years [Standard Deviation (SD: 12.8)], 60.4% males. 10% of patients (n = 15) were derived to ICU and/or died during admission. Median (IQR) sST2 serum concentration (ng/mL) rose to 53.1 (30.9) at admission, peaked at 48–72 h (79.5(64)) and returned to admission levels at discharge (44.9[36.7]). A concentration of sST2 above 58.9 ng/mL was identified patients progressing to ICU admission or death. Results remained significant after multivariable analysis. The area under the receiver operating characteristics curve (AUC) of sST2 for endpoints was 0.776 (p = 0.001). In patients admitted for COVID-19 infection, early measurement of sST2 was able to identify patients at risk of severe complications or death.
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spelling pubmed-83969942021-08-28 Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection Sánchez-Marteles, Marta Rubio-Gracia, Jorge Peña-Fresneda, Natacha Garcés-Horna, Vanesa Gracia-Tello, Borja Martínez-Lostao, Luis Crespo-Aznárez, Silvia Pérez-Calvo, Juan Ignacio Giménez-López, Ignacio J Clin Med Article Although several biomarkers have shown correlation to prognosis in COVID-19 patients, their clinical value is limited because of lack of specificity, suboptimal sensibility or poor dynamic behavior. We hypothesized that circulating soluble ST2 (sST2) could be associated to a worse outcome in COVID-19. In total, 152 patients admitted for confirmed COVID-19 were included in a prospective non-interventional, observational study. Blood samples were drawn at admission, 48–72 h later and at discharge. sST2 concentrations and routine blood laboratory were analyzed. Primary endpoints were admission at intensive care unit (ICU) and mortality. Median age was 57.5 years [Standard Deviation (SD: 12.8)], 60.4% males. 10% of patients (n = 15) were derived to ICU and/or died during admission. Median (IQR) sST2 serum concentration (ng/mL) rose to 53.1 (30.9) at admission, peaked at 48–72 h (79.5(64)) and returned to admission levels at discharge (44.9[36.7]). A concentration of sST2 above 58.9 ng/mL was identified patients progressing to ICU admission or death. Results remained significant after multivariable analysis. The area under the receiver operating characteristics curve (AUC) of sST2 for endpoints was 0.776 (p = 0.001). In patients admitted for COVID-19 infection, early measurement of sST2 was able to identify patients at risk of severe complications or death. MDPI 2021-08-11 /pmc/articles/PMC8396994/ /pubmed/34441830 http://dx.doi.org/10.3390/jcm10163534 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Marteles, Marta
Rubio-Gracia, Jorge
Peña-Fresneda, Natacha
Garcés-Horna, Vanesa
Gracia-Tello, Borja
Martínez-Lostao, Luis
Crespo-Aznárez, Silvia
Pérez-Calvo, Juan Ignacio
Giménez-López, Ignacio
Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title_full Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title_fullStr Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title_full_unstemmed Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title_short Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection
title_sort early measurement of blood sst2 is a good predictor of death and poor outcomes in patients admitted for covid-19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396994/
https://www.ncbi.nlm.nih.gov/pubmed/34441830
http://dx.doi.org/10.3390/jcm10163534
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