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Susceptibility of β-Thalassemia Heterozygotes to COVID-19
Background: β-Thalassemia is the most prevalent single gene blood disorder, while the assessment of its susceptibility to coronavirus disease 2019 (COVID-19) warrants it a pressing biomedical priority. Methods: We studied 255 positive COVID-19 participants unvaccinated against severe acute respirato...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397014/ https://www.ncbi.nlm.nih.gov/pubmed/34441941 http://dx.doi.org/10.3390/jcm10163645 |
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author | Sotiriou, Sotirios Samara, Athina A. Vamvakopoulou, Dimitra Vamvakopoulos, Konstantinos-Odysseas Sidiropoulos, Andreas Vamvakopoulos, Nikolaos Janho, Michel B. Gourgoulianis, Konstantinos I. Boutlas, Styllianos |
author_facet | Sotiriou, Sotirios Samara, Athina A. Vamvakopoulou, Dimitra Vamvakopoulos, Konstantinos-Odysseas Sidiropoulos, Andreas Vamvakopoulos, Nikolaos Janho, Michel B. Gourgoulianis, Konstantinos I. Boutlas, Styllianos |
author_sort | Sotiriou, Sotirios |
collection | PubMed |
description | Background: β-Thalassemia is the most prevalent single gene blood disorder, while the assessment of its susceptibility to coronavirus disease 2019 (COVID-19) warrants it a pressing biomedical priority. Methods: We studied 255 positive COVID-19 participants unvaccinated against severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), consecutively recruited during the last trimester of 2020. Patient characteristics including age, sex, current smoking status, atrial fibrillation, chronic respiratory disease, coronary disease, diabetes, neoplasia, hyperlipidemia, hypertension, and β-thalassemia heterozygosity were assessed for COVID-19 severity, length of hospitalization, intensive care unit (ICU) admission and mortality from COVID-19. Results: We assessed patient characteristics associated with clinical symptoms, ICU admission, and mortality from COVID-19. In multivariate analysis, severe-critical COVID-19 was strongly associated with male sex (p = 0.023), increased age (p < 0.001), and β-thalassemia heterozygosity (p = 0.002, OR = 2.89). Regarding the requirement for ICU care, in multivariate analysis there was a statistically significant association with hypertension (p = 0.001, OR = 5.12), while β-thalassemia heterozygosity had no effect (p = 0.508, OR = 1.33). Mortality was linked to male sex (p = 0.036, OR = 2.09), increased age (p < 0.001) and β-thalassemia heterozygosity (p = 0.010, OR = 2.79) in multivariate analysis. It is worth noting that hyperlipidemia reduced mortality from COVID-19 (p = 0.008, OR = 0.38). No statistically significant association of current smoking status with patient characteristics studied was observed. Conclusions: Our pilot observations indicate enhanced mortality of β-thalassemia heterozygotes from COVID-19. |
format | Online Article Text |
id | pubmed-8397014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83970142021-08-28 Susceptibility of β-Thalassemia Heterozygotes to COVID-19 Sotiriou, Sotirios Samara, Athina A. Vamvakopoulou, Dimitra Vamvakopoulos, Konstantinos-Odysseas Sidiropoulos, Andreas Vamvakopoulos, Nikolaos Janho, Michel B. Gourgoulianis, Konstantinos I. Boutlas, Styllianos J Clin Med Article Background: β-Thalassemia is the most prevalent single gene blood disorder, while the assessment of its susceptibility to coronavirus disease 2019 (COVID-19) warrants it a pressing biomedical priority. Methods: We studied 255 positive COVID-19 participants unvaccinated against severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), consecutively recruited during the last trimester of 2020. Patient characteristics including age, sex, current smoking status, atrial fibrillation, chronic respiratory disease, coronary disease, diabetes, neoplasia, hyperlipidemia, hypertension, and β-thalassemia heterozygosity were assessed for COVID-19 severity, length of hospitalization, intensive care unit (ICU) admission and mortality from COVID-19. Results: We assessed patient characteristics associated with clinical symptoms, ICU admission, and mortality from COVID-19. In multivariate analysis, severe-critical COVID-19 was strongly associated with male sex (p = 0.023), increased age (p < 0.001), and β-thalassemia heterozygosity (p = 0.002, OR = 2.89). Regarding the requirement for ICU care, in multivariate analysis there was a statistically significant association with hypertension (p = 0.001, OR = 5.12), while β-thalassemia heterozygosity had no effect (p = 0.508, OR = 1.33). Mortality was linked to male sex (p = 0.036, OR = 2.09), increased age (p < 0.001) and β-thalassemia heterozygosity (p = 0.010, OR = 2.79) in multivariate analysis. It is worth noting that hyperlipidemia reduced mortality from COVID-19 (p = 0.008, OR = 0.38). No statistically significant association of current smoking status with patient characteristics studied was observed. Conclusions: Our pilot observations indicate enhanced mortality of β-thalassemia heterozygotes from COVID-19. MDPI 2021-08-18 /pmc/articles/PMC8397014/ /pubmed/34441941 http://dx.doi.org/10.3390/jcm10163645 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sotiriou, Sotirios Samara, Athina A. Vamvakopoulou, Dimitra Vamvakopoulos, Konstantinos-Odysseas Sidiropoulos, Andreas Vamvakopoulos, Nikolaos Janho, Michel B. Gourgoulianis, Konstantinos I. Boutlas, Styllianos Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title | Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title_full | Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title_fullStr | Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title_full_unstemmed | Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title_short | Susceptibility of β-Thalassemia Heterozygotes to COVID-19 |
title_sort | susceptibility of β-thalassemia heterozygotes to covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397014/ https://www.ncbi.nlm.nih.gov/pubmed/34441941 http://dx.doi.org/10.3390/jcm10163645 |
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