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Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer

Introduction: A growing body of evidence suggests a strong association between atrial fibrillation (AF) and cancer. A relevant number of patients with a present or former malignant disease with highly symptomatic drug-refractory AF are in need of interventional therapy. Data on the safety and effica...

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Autores principales: Eitel, Charlotte, Sciacca, Vanessa, Bartels, Nina, Saraei, Roza, Fink, Thomas, Keelani, Ahmad, Gaßmann, André, Kuck, Karl-Heinz, Vogler, Julia, Heeger, Christian-Hendrik, Tilz, Roland Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397043/
https://www.ncbi.nlm.nih.gov/pubmed/34441965
http://dx.doi.org/10.3390/jcm10163669
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author Eitel, Charlotte
Sciacca, Vanessa
Bartels, Nina
Saraei, Roza
Fink, Thomas
Keelani, Ahmad
Gaßmann, André
Kuck, Karl-Heinz
Vogler, Julia
Heeger, Christian-Hendrik
Tilz, Roland Richard
author_facet Eitel, Charlotte
Sciacca, Vanessa
Bartels, Nina
Saraei, Roza
Fink, Thomas
Keelani, Ahmad
Gaßmann, André
Kuck, Karl-Heinz
Vogler, Julia
Heeger, Christian-Hendrik
Tilz, Roland Richard
author_sort Eitel, Charlotte
collection PubMed
description Introduction: A growing body of evidence suggests a strong association between atrial fibrillation (AF) and cancer. A relevant number of patients with a present or former malignant disease with highly symptomatic drug-refractory AF are in need of interventional therapy. Data on the safety and efficacy of catheter ablation in these patients are sparse. The present study aims to analyze the safety and efficacy of cryoballoon-based pulmonary vein isolation (CB-PVI) for symptomatic AF in patients with past or present cancer disease. Methods and Results: Consecutive patients undergoing CB-PVI for symptomatic AF at University Hospital Lübeck, Germany between July 2015 and January 2019 were included in this study. Propensity-score based matching was performed to identify comparable patients with and without cancer disease and further analyze clinical characteristics, periprocedural complications and arrhythmia-free survival. A total of 70 patients with a history of cancer undergoing CB-PVI were matched to 70 patients without a history of cancer. The frequency of complications was similar between patients with and without a history of cancer (p = 0.11), with four phrenic nerve palsies occurring in patients with a history of cancer (5.6% of the cohort) vs. one phrenic nerve palsy in patients without cancer (p = 0.36). Arrhythmia free survival after 12 months did not differ significantly in patients with and without a history of cancer (67.1 ± 5.8% vs. 77.8% ± 5.1%, p = 0.16). Conclusion: This study indicates that CB-PVI for symptomatic AF is equally safe and effective in patients with and without a history of cancer and cancer treatment.
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spelling pubmed-83970432021-08-28 Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer Eitel, Charlotte Sciacca, Vanessa Bartels, Nina Saraei, Roza Fink, Thomas Keelani, Ahmad Gaßmann, André Kuck, Karl-Heinz Vogler, Julia Heeger, Christian-Hendrik Tilz, Roland Richard J Clin Med Article Introduction: A growing body of evidence suggests a strong association between atrial fibrillation (AF) and cancer. A relevant number of patients with a present or former malignant disease with highly symptomatic drug-refractory AF are in need of interventional therapy. Data on the safety and efficacy of catheter ablation in these patients are sparse. The present study aims to analyze the safety and efficacy of cryoballoon-based pulmonary vein isolation (CB-PVI) for symptomatic AF in patients with past or present cancer disease. Methods and Results: Consecutive patients undergoing CB-PVI for symptomatic AF at University Hospital Lübeck, Germany between July 2015 and January 2019 were included in this study. Propensity-score based matching was performed to identify comparable patients with and without cancer disease and further analyze clinical characteristics, periprocedural complications and arrhythmia-free survival. A total of 70 patients with a history of cancer undergoing CB-PVI were matched to 70 patients without a history of cancer. The frequency of complications was similar between patients with and without a history of cancer (p = 0.11), with four phrenic nerve palsies occurring in patients with a history of cancer (5.6% of the cohort) vs. one phrenic nerve palsy in patients without cancer (p = 0.36). Arrhythmia free survival after 12 months did not differ significantly in patients with and without a history of cancer (67.1 ± 5.8% vs. 77.8% ± 5.1%, p = 0.16). Conclusion: This study indicates that CB-PVI for symptomatic AF is equally safe and effective in patients with and without a history of cancer and cancer treatment. MDPI 2021-08-19 /pmc/articles/PMC8397043/ /pubmed/34441965 http://dx.doi.org/10.3390/jcm10163669 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eitel, Charlotte
Sciacca, Vanessa
Bartels, Nina
Saraei, Roza
Fink, Thomas
Keelani, Ahmad
Gaßmann, André
Kuck, Karl-Heinz
Vogler, Julia
Heeger, Christian-Hendrik
Tilz, Roland Richard
Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title_full Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title_fullStr Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title_full_unstemmed Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title_short Safety and Efficacy of Cryoballoon Based Pulmonary Vein Isolation in Patients with Atrial Fibrillation and a History of Cancer
title_sort safety and efficacy of cryoballoon based pulmonary vein isolation in patients with atrial fibrillation and a history of cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397043/
https://www.ncbi.nlm.nih.gov/pubmed/34441965
http://dx.doi.org/10.3390/jcm10163669
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