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Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation

In order to successfully infect or colonize human hosts or survive changing environments, Aspergillus fumigatus needs to adapt through genetic changes or phenotypic plasticity. The genomic changes are based on the capacity of the fungus to produce genetic variation, followed by selection of the geno...

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Autores principales: Zhang, Jianhua, Debets, Alfons J. M., Verweij, Paul E., Snelders, Eveline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397044/
https://www.ncbi.nlm.nih.gov/pubmed/34436138
http://dx.doi.org/10.3390/jof7080599
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author Zhang, Jianhua
Debets, Alfons J. M.
Verweij, Paul E.
Snelders, Eveline
author_facet Zhang, Jianhua
Debets, Alfons J. M.
Verweij, Paul E.
Snelders, Eveline
author_sort Zhang, Jianhua
collection PubMed
description In order to successfully infect or colonize human hosts or survive changing environments, Aspergillus fumigatus needs to adapt through genetic changes or phenotypic plasticity. The genomic changes are based on the capacity of the fungus to produce genetic variation, followed by selection of the genotypes that are most fit to the new environment. Much scientific work has focused on the metabolic plasticity, biofilm formation or the particular genetic changes themselves leading to adaptation, such as antifungal resistance in the host. Recent scientific work has shown advances made in understanding the natural relevance of parasex and how both the asexual and sexual reproduction can lead to tandem repeat elongation in the target gene of the azoles: the cyp51A gene. In this review, we will explain how the fungus can generate genetic variation that can lead to adaptation. We will discuss recent advances that have been made in the understanding of the lifecycle of A. fumigatus to explain the differences observed in speed and type of mutations that are generated under different environments and how this can facilitate adaptation, such as azole-resistance selection.
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spelling pubmed-83970442021-08-28 Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation Zhang, Jianhua Debets, Alfons J. M. Verweij, Paul E. Snelders, Eveline J Fungi (Basel) Review In order to successfully infect or colonize human hosts or survive changing environments, Aspergillus fumigatus needs to adapt through genetic changes or phenotypic plasticity. The genomic changes are based on the capacity of the fungus to produce genetic variation, followed by selection of the genotypes that are most fit to the new environment. Much scientific work has focused on the metabolic plasticity, biofilm formation or the particular genetic changes themselves leading to adaptation, such as antifungal resistance in the host. Recent scientific work has shown advances made in understanding the natural relevance of parasex and how both the asexual and sexual reproduction can lead to tandem repeat elongation in the target gene of the azoles: the cyp51A gene. In this review, we will explain how the fungus can generate genetic variation that can lead to adaptation. We will discuss recent advances that have been made in the understanding of the lifecycle of A. fumigatus to explain the differences observed in speed and type of mutations that are generated under different environments and how this can facilitate adaptation, such as azole-resistance selection. MDPI 2021-07-24 /pmc/articles/PMC8397044/ /pubmed/34436138 http://dx.doi.org/10.3390/jof7080599 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Jianhua
Debets, Alfons J. M.
Verweij, Paul E.
Snelders, Eveline
Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title_full Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title_fullStr Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title_full_unstemmed Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title_short Azole-Resistance Development; How the Aspergillus fumigatus Lifecycle Defines the Potential for Adaptation
title_sort azole-resistance development; how the aspergillus fumigatus lifecycle defines the potential for adaptation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397044/
https://www.ncbi.nlm.nih.gov/pubmed/34436138
http://dx.doi.org/10.3390/jof7080599
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