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Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest

Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index...

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Autores principales: Goudzwaard, Jeannette A., Chotkan, Sadhna, De Ronde-Tillmans, Marjo J. A. G., Lenzen, Mattie J., van Wiechen, Maarten P. H., Ooms, Joris F. W., Polinder-Bos, Harmke A., de Beer-Leentfaar, Madelon, Van Mieghem, Nicolas M., Daemen, Joost, Pilotto, Alberto, de Jaegere, Peter P. T., Mattace-Raso, Francesco U. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397063/
https://www.ncbi.nlm.nih.gov/pubmed/34441825
http://dx.doi.org/10.3390/jcm10163529
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author Goudzwaard, Jeannette A.
Chotkan, Sadhna
De Ronde-Tillmans, Marjo J. A. G.
Lenzen, Mattie J.
van Wiechen, Maarten P. H.
Ooms, Joris F. W.
Polinder-Bos, Harmke A.
de Beer-Leentfaar, Madelon
Van Mieghem, Nicolas M.
Daemen, Joost
Pilotto, Alberto
de Jaegere, Peter P. T.
Mattace-Raso, Francesco U. S.
author_facet Goudzwaard, Jeannette A.
Chotkan, Sadhna
De Ronde-Tillmans, Marjo J. A. G.
Lenzen, Mattie J.
van Wiechen, Maarten P. H.
Ooms, Joris F. W.
Polinder-Bos, Harmke A.
de Beer-Leentfaar, Madelon
Van Mieghem, Nicolas M.
Daemen, Joost
Pilotto, Alberto
de Jaegere, Peter P. T.
Mattace-Raso, Francesco U. S.
author_sort Goudzwaard, Jeannette A.
collection PubMed
description Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (p = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure.
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spelling pubmed-83970632021-08-28 Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest Goudzwaard, Jeannette A. Chotkan, Sadhna De Ronde-Tillmans, Marjo J. A. G. Lenzen, Mattie J. van Wiechen, Maarten P. H. Ooms, Joris F. W. Polinder-Bos, Harmke A. de Beer-Leentfaar, Madelon Van Mieghem, Nicolas M. Daemen, Joost Pilotto, Alberto de Jaegere, Peter P. T. Mattace-Raso, Francesco U. S. J Clin Med Article Selecting patients with a high chance of endured benefit from transcatheter aortic valve implantation (TAVI) is becoming relevant with changing indications and increasing number of TAVI being performed. The aim of our study was to investigate the association of the multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) on survival. The TAVI Care & Cure program is a prospective, observational registry of patients referred for TAVI at the Erasmus MC University Medical Center. Consecutive patients who underwent a complete CGA and TAVI were included. CGA components were used to calculate the MPI score. The impact of the MPI score on survival was evaluated using Cox regression. Furthermore, 376 patients were included, 143 (38.0%) patients belonged to the MPI-1 group and 233 (61.9%) patients to the MPI-2–3 group. After 3 years, 14.9% of the patients in the MPI-1 group and 30.5% of the patients in the MPI-2–3 group died (p = 0.001). Patients in MPI-1 had increased chances of overall survival in comparison with patients in MPI group 2–3 Hazard Ratio (HR) 0.57, (95% Confidence Interval (CI) 0.33–0.98)). In this study we found that the MPI tool could be useful to assess frailty and to predict which patient will have a higher chance of enduring benefit from a TAVI procedure. MDPI 2021-08-11 /pmc/articles/PMC8397063/ /pubmed/34441825 http://dx.doi.org/10.3390/jcm10163529 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goudzwaard, Jeannette A.
Chotkan, Sadhna
De Ronde-Tillmans, Marjo J. A. G.
Lenzen, Mattie J.
van Wiechen, Maarten P. H.
Ooms, Joris F. W.
Polinder-Bos, Harmke A.
de Beer-Leentfaar, Madelon
Van Mieghem, Nicolas M.
Daemen, Joost
Pilotto, Alberto
de Jaegere, Peter P. T.
Mattace-Raso, Francesco U. S.
Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title_full Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title_fullStr Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title_full_unstemmed Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title_short Multidimensional Prognostic Index and Outcomes in Older Patients Undergoing Transcatheter Aortic Valve Implantation: Survival of the Fittest
title_sort multidimensional prognostic index and outcomes in older patients undergoing transcatheter aortic valve implantation: survival of the fittest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397063/
https://www.ncbi.nlm.nih.gov/pubmed/34441825
http://dx.doi.org/10.3390/jcm10163529
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