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Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome

Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hos...

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Autores principales: Real de Asua, Diego, Mayer, Miguel A., Ortega, María del Carmen, Borrel, Jose M., Bermejo, Teresa de Jesús, González-Lamuño, Domingo, Manso, Coral, Moldenhauer, Fernando, Carmona-Iragui, María, Hüls, Anke, Sherman, Stephanie L., Strydom, Andre, de la Torre, Rafael, Dierssen, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397064/
https://www.ncbi.nlm.nih.gov/pubmed/34442043
http://dx.doi.org/10.3390/jcm10163748
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author Real de Asua, Diego
Mayer, Miguel A.
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González-Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona-Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
de la Torre, Rafael
Dierssen, Mara
author_facet Real de Asua, Diego
Mayer, Miguel A.
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González-Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona-Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
de la Torre, Rafael
Dierssen, Mara
author_sort Real de Asua, Diego
collection PubMed
description Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19.
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spelling pubmed-83970642021-08-28 Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome Real de Asua, Diego Mayer, Miguel A. Ortega, María del Carmen Borrel, Jose M. Bermejo, Teresa de Jesús González-Lamuño, Domingo Manso, Coral Moldenhauer, Fernando Carmona-Iragui, María Hüls, Anke Sherman, Stephanie L. Strydom, Andre de la Torre, Rafael Dierssen, Mara J Clin Med Article Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19. MDPI 2021-08-23 /pmc/articles/PMC8397064/ /pubmed/34442043 http://dx.doi.org/10.3390/jcm10163748 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Real de Asua, Diego
Mayer, Miguel A.
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González-Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona-Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
de la Torre, Rafael
Dierssen, Mara
Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title_full Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title_fullStr Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title_full_unstemmed Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title_short Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome
title_sort comparison of covid-19 and non-covid-19 pneumonia in down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397064/
https://www.ncbi.nlm.nih.gov/pubmed/34442043
http://dx.doi.org/10.3390/jcm10163748
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