Cargando…

Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids

The exact mechanism of selective progesterone receptor modulator action in leiomyoma still challenges researchers. The aim of the study was to assess the effects of ulipristal acetate (UPA) on immunoexpression of inflammatory markers and vascularization in fibroids. UPA-treated patients were divided...

Descripción completa

Detalles Bibliográficos
Autores principales: Szydłowska, Iwona, Grabowska, Marta, Nawrocka-Rutkowska, Jolanta, Kram, Andrzej, Piasecka, Małgorzata, Starczewski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397116/
https://www.ncbi.nlm.nih.gov/pubmed/34442017
http://dx.doi.org/10.3390/jcm10163721
_version_ 1783744542171725824
author Szydłowska, Iwona
Grabowska, Marta
Nawrocka-Rutkowska, Jolanta
Kram, Andrzej
Piasecka, Małgorzata
Starczewski, Andrzej
author_facet Szydłowska, Iwona
Grabowska, Marta
Nawrocka-Rutkowska, Jolanta
Kram, Andrzej
Piasecka, Małgorzata
Starczewski, Andrzej
author_sort Szydłowska, Iwona
collection PubMed
description The exact mechanism of selective progesterone receptor modulator action in leiomyoma still challenges researchers. The aim of the study was to assess the effects of ulipristal acetate (UPA) on immunoexpression of inflammatory markers and vascularization in fibroids. UPA-treated patients were divided into three groups: (1) good response (≥25% reduction in volume of fibroid), (2) weak response (insignificant volume reduction), (3) and no response to treatment (no decrease or increase in fibroid volume). The percentage of TGFβ, IL6, IL10, CD117, and CD68-positive cells were significantly lower in the group with a good response to treatment vs. the control group. Moreover, the percentage of IL10 and CD68-positive cells in the group with a good response to treatment were also significantly lower compared to the no response group. Additionally, a significant decrease in the percentage of IL10-positive cells was found in the good response group vs. the weak response group. There were no statistical differences in the percentage of TNFα-positive cells and vessel parameters between all compared groups. The results of the study indicate that a good response to UPA treatment may be associated with a decrease of inflammatory markers, but it does not influence myoma vascularization.
format Online
Article
Text
id pubmed-8397116
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83971162021-08-28 Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids Szydłowska, Iwona Grabowska, Marta Nawrocka-Rutkowska, Jolanta Kram, Andrzej Piasecka, Małgorzata Starczewski, Andrzej J Clin Med Article The exact mechanism of selective progesterone receptor modulator action in leiomyoma still challenges researchers. The aim of the study was to assess the effects of ulipristal acetate (UPA) on immunoexpression of inflammatory markers and vascularization in fibroids. UPA-treated patients were divided into three groups: (1) good response (≥25% reduction in volume of fibroid), (2) weak response (insignificant volume reduction), (3) and no response to treatment (no decrease or increase in fibroid volume). The percentage of TGFβ, IL6, IL10, CD117, and CD68-positive cells were significantly lower in the group with a good response to treatment vs. the control group. Moreover, the percentage of IL10 and CD68-positive cells in the group with a good response to treatment were also significantly lower compared to the no response group. Additionally, a significant decrease in the percentage of IL10-positive cells was found in the good response group vs. the weak response group. There were no statistical differences in the percentage of TNFα-positive cells and vessel parameters between all compared groups. The results of the study indicate that a good response to UPA treatment may be associated with a decrease of inflammatory markers, but it does not influence myoma vascularization. MDPI 2021-08-21 /pmc/articles/PMC8397116/ /pubmed/34442017 http://dx.doi.org/10.3390/jcm10163721 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szydłowska, Iwona
Grabowska, Marta
Nawrocka-Rutkowska, Jolanta
Kram, Andrzej
Piasecka, Małgorzata
Starczewski, Andrzej
Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title_full Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title_fullStr Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title_full_unstemmed Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title_short Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids
title_sort markers of inflammation and vascular parameters in selective progesterone receptor modulator (ulipristal acetate)-treated uterine fibroids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397116/
https://www.ncbi.nlm.nih.gov/pubmed/34442017
http://dx.doi.org/10.3390/jcm10163721
work_keys_str_mv AT szydłowskaiwona markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids
AT grabowskamarta markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids
AT nawrockarutkowskajolanta markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids
AT kramandrzej markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids
AT piaseckamałgorzata markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids
AT starczewskiandrzej markersofinflammationandvascularparametersinselectiveprogesteronereceptormodulatorulipristalacetatetreateduterinefibroids