Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives

Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance...

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Autores principales: Lavalle, Carlo, Trivigno, Sara, Vetta, Giampaolo, Magnocavallo, Michele, Mariani, Marco Valerio, Santini, Luca, Forleo, Giovanni Battista, Grimaldi, Massimo, Badagliacca, Roberto, Lanata, Luigi, Ricci, Renato Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397118/
https://www.ncbi.nlm.nih.gov/pubmed/34441994
http://dx.doi.org/10.3390/jcm10163696
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author Lavalle, Carlo
Trivigno, Sara
Vetta, Giampaolo
Magnocavallo, Michele
Mariani, Marco Valerio
Santini, Luca
Forleo, Giovanni Battista
Grimaldi, Massimo
Badagliacca, Roberto
Lanata, Luigi
Ricci, Renato Pietro
author_facet Lavalle, Carlo
Trivigno, Sara
Vetta, Giampaolo
Magnocavallo, Michele
Mariani, Marco Valerio
Santini, Luca
Forleo, Giovanni Battista
Grimaldi, Massimo
Badagliacca, Roberto
Lanata, Luigi
Ricci, Renato Pietro
author_sort Lavalle, Carlo
collection PubMed
description Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular arrhythmias (IVA) in absence of ischaemic and structural heart disease on the basis of CAST data. Recent studies enrolling patients with different structural heart diseases demonstrated good effectiveness and safety profile of flecainide. The purpose of this review is to assess current evidence for appropriate and safe use of flecainide, 30 years after CAST data, in the light of new diagnostic and therapeutic tools in the field of ischaemic and non-ischaemic heart disease.
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spelling pubmed-83971182021-08-28 Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives Lavalle, Carlo Trivigno, Sara Vetta, Giampaolo Magnocavallo, Michele Mariani, Marco Valerio Santini, Luca Forleo, Giovanni Battista Grimaldi, Massimo Badagliacca, Roberto Lanata, Luigi Ricci, Renato Pietro J Clin Med Review Flecainide is an IC antiarrhythmic drug (AAD) that received in 1984 Food and Drug Administration approval for the treatment of sustained ventricular tachycardia (VT) and subsequently for rhythm control of atrial fibrillation (AF). Currently, flecainide is mainly employed for sinus rhythm maintenance in AF and the treatment of idiopathic ventricular arrhythmias (IVA) in absence of ischaemic and structural heart disease on the basis of CAST data. Recent studies enrolling patients with different structural heart diseases demonstrated good effectiveness and safety profile of flecainide. The purpose of this review is to assess current evidence for appropriate and safe use of flecainide, 30 years after CAST data, in the light of new diagnostic and therapeutic tools in the field of ischaemic and non-ischaemic heart disease. MDPI 2021-08-20 /pmc/articles/PMC8397118/ /pubmed/34441994 http://dx.doi.org/10.3390/jcm10163696 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lavalle, Carlo
Trivigno, Sara
Vetta, Giampaolo
Magnocavallo, Michele
Mariani, Marco Valerio
Santini, Luca
Forleo, Giovanni Battista
Grimaldi, Massimo
Badagliacca, Roberto
Lanata, Luigi
Ricci, Renato Pietro
Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title_full Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title_fullStr Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title_full_unstemmed Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title_short Flecainide in Ventricular Arrhythmias: From Old Myths to New Perspectives
title_sort flecainide in ventricular arrhythmias: from old myths to new perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397118/
https://www.ncbi.nlm.nih.gov/pubmed/34441994
http://dx.doi.org/10.3390/jcm10163696
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