Cargando…

An epigenetic basis of inbreeding depression in maize

Inbreeding depression is widespread across plant and animal kingdoms and may arise from the exposure of deleterious alleles and/or loss of overdominant alleles resulting from increased homozygosity, but these genetic models cannot fully explain the phenomenon. Here, we report epigenetic links to inb...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Tongwen, Wang, Fang, Song, Qingxin, Ye, Wenxue, Liu, Tieshan, Wang, Liming, Chen, Z. Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397266/
https://www.ncbi.nlm.nih.gov/pubmed/34452913
http://dx.doi.org/10.1126/sciadv.abg5442
_version_ 1783744576431849472
author Han, Tongwen
Wang, Fang
Song, Qingxin
Ye, Wenxue
Liu, Tieshan
Wang, Liming
Chen, Z. Jeffrey
author_facet Han, Tongwen
Wang, Fang
Song, Qingxin
Ye, Wenxue
Liu, Tieshan
Wang, Liming
Chen, Z. Jeffrey
author_sort Han, Tongwen
collection PubMed
description Inbreeding depression is widespread across plant and animal kingdoms and may arise from the exposure of deleterious alleles and/or loss of overdominant alleles resulting from increased homozygosity, but these genetic models cannot fully explain the phenomenon. Here, we report epigenetic links to inbreeding depression in maize. Teosinte branched1/cycloidea/proliferating cell factor (TCP) transcription factors control plant development. During successive inbreeding among inbred lines, thousands of genomic regions across TCP-binding sites (TBS) are hypermethylated through the H3K9me2-mediated pathway. These hypermethylated regions are accompanied by decreased chromatin accessibility, increased levels of the repressive histone marks H3K27me2 and H3K27me3, and reduced binding affinity of maize TCP-proteins to TBS. Consequently, hundreds of TCP-target genes involved in mitochondrion, chloroplast, and ribosome functions are down-regulated, leading to reduced growth vigor. Conversely, random mating can reverse corresponding hypermethylation sites and TCP-target gene expression, restoring growth vigor. These results support a unique role of reversible epigenetic modifications in inbreeding depression.
format Online
Article
Text
id pubmed-8397266
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-83972662021-09-09 An epigenetic basis of inbreeding depression in maize Han, Tongwen Wang, Fang Song, Qingxin Ye, Wenxue Liu, Tieshan Wang, Liming Chen, Z. Jeffrey Sci Adv Research Articles Inbreeding depression is widespread across plant and animal kingdoms and may arise from the exposure of deleterious alleles and/or loss of overdominant alleles resulting from increased homozygosity, but these genetic models cannot fully explain the phenomenon. Here, we report epigenetic links to inbreeding depression in maize. Teosinte branched1/cycloidea/proliferating cell factor (TCP) transcription factors control plant development. During successive inbreeding among inbred lines, thousands of genomic regions across TCP-binding sites (TBS) are hypermethylated through the H3K9me2-mediated pathway. These hypermethylated regions are accompanied by decreased chromatin accessibility, increased levels of the repressive histone marks H3K27me2 and H3K27me3, and reduced binding affinity of maize TCP-proteins to TBS. Consequently, hundreds of TCP-target genes involved in mitochondrion, chloroplast, and ribosome functions are down-regulated, leading to reduced growth vigor. Conversely, random mating can reverse corresponding hypermethylation sites and TCP-target gene expression, restoring growth vigor. These results support a unique role of reversible epigenetic modifications in inbreeding depression. American Association for the Advancement of Science 2021-08-27 /pmc/articles/PMC8397266/ /pubmed/34452913 http://dx.doi.org/10.1126/sciadv.abg5442 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Han, Tongwen
Wang, Fang
Song, Qingxin
Ye, Wenxue
Liu, Tieshan
Wang, Liming
Chen, Z. Jeffrey
An epigenetic basis of inbreeding depression in maize
title An epigenetic basis of inbreeding depression in maize
title_full An epigenetic basis of inbreeding depression in maize
title_fullStr An epigenetic basis of inbreeding depression in maize
title_full_unstemmed An epigenetic basis of inbreeding depression in maize
title_short An epigenetic basis of inbreeding depression in maize
title_sort epigenetic basis of inbreeding depression in maize
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397266/
https://www.ncbi.nlm.nih.gov/pubmed/34452913
http://dx.doi.org/10.1126/sciadv.abg5442
work_keys_str_mv AT hantongwen anepigeneticbasisofinbreedingdepressioninmaize
AT wangfang anepigeneticbasisofinbreedingdepressioninmaize
AT songqingxin anepigeneticbasisofinbreedingdepressioninmaize
AT yewenxue anepigeneticbasisofinbreedingdepressioninmaize
AT liutieshan anepigeneticbasisofinbreedingdepressioninmaize
AT wangliming anepigeneticbasisofinbreedingdepressioninmaize
AT chenzjeffrey anepigeneticbasisofinbreedingdepressioninmaize
AT hantongwen epigeneticbasisofinbreedingdepressioninmaize
AT wangfang epigeneticbasisofinbreedingdepressioninmaize
AT songqingxin epigeneticbasisofinbreedingdepressioninmaize
AT yewenxue epigeneticbasisofinbreedingdepressioninmaize
AT liutieshan epigeneticbasisofinbreedingdepressioninmaize
AT wangliming epigeneticbasisofinbreedingdepressioninmaize
AT chenzjeffrey epigeneticbasisofinbreedingdepressioninmaize