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Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PADI4) catalyzes the deimination of histone arginine residues to citrulline. Here, we demonstrate that PADI4 expression is induced by hypo...

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Detalles Bibliográficos
Autores principales:	Wang, Yufeng, Lyu, Yajing, Tu, Kangsheng, Xu, Qiuran, Yang, Yongkang, Salman, Shaima, Le, Nguyet, Lu, Haiquan, Chen, Chelsey, Zhu, Yayun, Wang, Ru, Liu, Qingguang, Semenza, Gregg L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397272/ https://www.ncbi.nlm.nih.gov/pubmed/34452909 http://dx.doi.org/10.1126/sciadv.abe3771

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