High-purity production and precise editing of DNA base editing ribonucleoproteins

Ribonucleoprotein (RNP) complex–mediated base editing is expected to be greatly beneficial because of its reduced off-target effects compared to plasmid- or viral vector–mediated gene editing, especially in therapeutic applications. However, production of recombinant cytosine base editors (CBEs) or...

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Detalles Bibliográficos
Autores principales: Jang, Hyeon-Ki, Jo, Dong Hyun, Lee, Seu-Na, Cho, Chang Sik, Jeong, You Kyeong, Jung, Youngri, Yu, Jihyeon, Kim, Jeong Hun, Woo, Jae-Sung, Bae, Sangsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397273/
https://www.ncbi.nlm.nih.gov/pubmed/34452911
http://dx.doi.org/10.1126/sciadv.abg2661

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