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Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

The class IB phosphoinositide 3-kinase (PI3K), PI3Kγ, is a master regulator of immune cell function and a promising drug target for both cancer and inflammatory diseases. Critical to PI3Kγ function is the association of the p110γ catalytic subunit to either a p101 or p84 regulatory subunit, which me...

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Detalles Bibliográficos
Autores principales:	Rathinaswamy, Manoj K., Dalwadi, Udit, Fleming, Kaelin D., Adams, Carson, Stariha, Jordan T. B., Pardon, Els, Baek, Minkyung, Vadas, Oscar, DiMaio, Frank, Steyaert, Jan, Hansen, Scott D., Yip, Calvin K., Burke, John E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397274/ https://www.ncbi.nlm.nih.gov/pubmed/34452907 http://dx.doi.org/10.1126/sciadv.abj4282

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