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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

[Image: see text] Physiologically based pharmacokinetic (PBPK) models are increasingly used in drug development to simulate changes in both systemic and tissue exposures that arise as a result of changes in enzyme and/or transporter activity. Verification of these model-based simulations of tissue e...

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Detalles Bibliográficos
Autores principales:	Scotcher, Daniel, Melillo, Nicola, Tadimalla, Sirisha, Darwich, Adam S., Ziemian, Sabina, Ogungbenro, Kayode, Schütz, Gunnar, Sourbron, Steven, Galetin, Aleksandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397403/ https://www.ncbi.nlm.nih.gov/pubmed/34283621 http://dx.doi.org/10.1021/acs.molpharmaceut.1c00206

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