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Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
[Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397430/ https://www.ncbi.nlm.nih.gov/pubmed/34264056 http://dx.doi.org/10.1021/acsnano.1c00955 |
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author | Sicard, François Toro-Mendoza, Jhoan |
author_facet | Sicard, François Toro-Mendoza, Jhoan |
author_sort | Sicard, François |
collection | PubMed |
description | [Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their ability to simultaneously adapt their morphology and functionality to complex ambients. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated by external stimuli. Here, we report on the computational design of a distinctive class of soft nanocarriers, built from armored nanodroplets, able to selectively encapsulate or release a probe load under specific flow conditions. First, we describe in detail the mechanisms at play in the formation of pocket-like structures in armored nanodroplets and their stability under external flow. Then we use that knowledge to test the capacity of these pockets to yield flow-assisted encapsulation or expulsion of a probe load. Finally, the rheological properties of these nanocarriers are put into perspective with those of delivery systems employed in pharmaceutical and cosmetic technology. |
format | Online Article Text |
id | pubmed-8397430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-83974302021-08-31 Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions Sicard, François Toro-Mendoza, Jhoan ACS Nano [Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their ability to simultaneously adapt their morphology and functionality to complex ambients. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated by external stimuli. Here, we report on the computational design of a distinctive class of soft nanocarriers, built from armored nanodroplets, able to selectively encapsulate or release a probe load under specific flow conditions. First, we describe in detail the mechanisms at play in the formation of pocket-like structures in armored nanodroplets and their stability under external flow. Then we use that knowledge to test the capacity of these pockets to yield flow-assisted encapsulation or expulsion of a probe load. Finally, the rheological properties of these nanocarriers are put into perspective with those of delivery systems employed in pharmaceutical and cosmetic technology. American Chemical Society 2021-07-15 2021-07-27 /pmc/articles/PMC8397430/ /pubmed/34264056 http://dx.doi.org/10.1021/acsnano.1c00955 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Sicard, François Toro-Mendoza, Jhoan Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions |
title | Armored
Droplets as Soft Nanocarriers for Encapsulation
and Release under Flow Conditions |
title_full | Armored
Droplets as Soft Nanocarriers for Encapsulation
and Release under Flow Conditions |
title_fullStr | Armored
Droplets as Soft Nanocarriers for Encapsulation
and Release under Flow Conditions |
title_full_unstemmed | Armored
Droplets as Soft Nanocarriers for Encapsulation
and Release under Flow Conditions |
title_short | Armored
Droplets as Soft Nanocarriers for Encapsulation
and Release under Flow Conditions |
title_sort | armored
droplets as soft nanocarriers for encapsulation
and release under flow conditions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397430/ https://www.ncbi.nlm.nih.gov/pubmed/34264056 http://dx.doi.org/10.1021/acsnano.1c00955 |
work_keys_str_mv | AT sicardfrancois armoreddropletsassoftnanocarriersforencapsulationandreleaseunderflowconditions AT toromendozajhoan armoreddropletsassoftnanocarriersforencapsulationandreleaseunderflowconditions |