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Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions

[Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their a...

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Autores principales: Sicard, François, Toro-Mendoza, Jhoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397430/
https://www.ncbi.nlm.nih.gov/pubmed/34264056
http://dx.doi.org/10.1021/acsnano.1c00955
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author Sicard, François
Toro-Mendoza, Jhoan
author_facet Sicard, François
Toro-Mendoza, Jhoan
author_sort Sicard, François
collection PubMed
description [Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their ability to simultaneously adapt their morphology and functionality to complex ambients. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated by external stimuli. Here, we report on the computational design of a distinctive class of soft nanocarriers, built from armored nanodroplets, able to selectively encapsulate or release a probe load under specific flow conditions. First, we describe in detail the mechanisms at play in the formation of pocket-like structures in armored nanodroplets and their stability under external flow. Then we use that knowledge to test the capacity of these pockets to yield flow-assisted encapsulation or expulsion of a probe load. Finally, the rheological properties of these nanocarriers are put into perspective with those of delivery systems employed in pharmaceutical and cosmetic technology.
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spelling pubmed-83974302021-08-31 Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions Sicard, François Toro-Mendoza, Jhoan ACS Nano [Image: see text] Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their ability to simultaneously adapt their morphology and functionality to complex ambients. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated by external stimuli. Here, we report on the computational design of a distinctive class of soft nanocarriers, built from armored nanodroplets, able to selectively encapsulate or release a probe load under specific flow conditions. First, we describe in detail the mechanisms at play in the formation of pocket-like structures in armored nanodroplets and their stability under external flow. Then we use that knowledge to test the capacity of these pockets to yield flow-assisted encapsulation or expulsion of a probe load. Finally, the rheological properties of these nanocarriers are put into perspective with those of delivery systems employed in pharmaceutical and cosmetic technology. American Chemical Society 2021-07-15 2021-07-27 /pmc/articles/PMC8397430/ /pubmed/34264056 http://dx.doi.org/10.1021/acsnano.1c00955 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Sicard, François
Toro-Mendoza, Jhoan
Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title_full Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title_fullStr Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title_full_unstemmed Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title_short Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions
title_sort armored droplets as soft nanocarriers for encapsulation and release under flow conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397430/
https://www.ncbi.nlm.nih.gov/pubmed/34264056
http://dx.doi.org/10.1021/acsnano.1c00955
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