Identification of BRCA2 Cis Double Heterozygous Breast Cancer Cases Using Whole Exome Sequencing: Phenotypic Expression and Impact on Personalized Oncology

BRCA1 and BRCA2 are the most commonly mutated breast cancer susceptibility genes that convey a high risk of breast and ovarian cancer. Most BRCA1 or BRCA2 mutation carriers have inherited a single heterozygous mutation. In recent years, very rare cases with biallelic or trans double heterozygous mut...

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Detalles Bibliográficos
Autores principales: Hamdi, Yosr, Boujemaa, Maroua, Mighri, Najah, Mejri, Nesrine, Jaidane, Olfa, Ben Nasr, Sonia, Bouaziz, Hanen, Hassouna, Jamel Ben, Zribi, Aref, Berrazaga, Yossra, Rachdi, Haifa, Daoud, Nouha, El Benna, Houda, Labidi, Soumaya, Haddaoui, Abderrazek, Rahal, Khaled, Benna, Farouk, Boussen, Hamouda, Abdelhak, Sonia, Boubaker, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397457/
https://www.ncbi.nlm.nih.gov/pubmed/34456966
http://dx.doi.org/10.3389/fgene.2021.674990

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