Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated wi...

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Autores principales: Pourmoghaddas, Zahra, Sadeghizadeh, Atefeh, Tara, Seyedeh Zahra, Zandifar, Alireza, Rahimi, Hamid, Saleh, Rana, Ghazavi, Mohammadreza, Yaghini, Omid, Hosseini, Neda, Javadi, Niloofar, Saadatnia, Mohammad, Vossough, Arastoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397488/
https://www.ncbi.nlm.nih.gov/pubmed/34517154
http://dx.doi.org/10.1016/j.jneuroim.2021.577704
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author Pourmoghaddas, Zahra
Sadeghizadeh, Atefeh
Tara, Seyedeh Zahra
Zandifar, Alireza
Rahimi, Hamid
Saleh, Rana
Ghazavi, Mohammadreza
Yaghini, Omid
Hosseini, Neda
Javadi, Niloofar
Saadatnia, Mohammad
Vossough, Arastoo
author_facet Pourmoghaddas, Zahra
Sadeghizadeh, Atefeh
Tara, Seyedeh Zahra
Zandifar, Alireza
Rahimi, Hamid
Saleh, Rana
Ghazavi, Mohammadreza
Yaghini, Omid
Hosseini, Neda
Javadi, Niloofar
Saadatnia, Mohammad
Vossough, Arastoo
author_sort Pourmoghaddas, Zahra
collection PubMed
description COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.
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spelling pubmed-83974882021-08-30 Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report Pourmoghaddas, Zahra Sadeghizadeh, Atefeh Tara, Seyedeh Zahra Zandifar, Alireza Rahimi, Hamid Saleh, Rana Ghazavi, Mohammadreza Yaghini, Omid Hosseini, Neda Javadi, Niloofar Saadatnia, Mohammad Vossough, Arastoo J Neuroimmunol Short Communication COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis. Elsevier B.V. 2021-11-15 2021-08-28 /pmc/articles/PMC8397488/ /pubmed/34517154 http://dx.doi.org/10.1016/j.jneuroim.2021.577704 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Pourmoghaddas, Zahra
Sadeghizadeh, Atefeh
Tara, Seyedeh Zahra
Zandifar, Alireza
Rahimi, Hamid
Saleh, Rana
Ghazavi, Mohammadreza
Yaghini, Omid
Hosseini, Neda
Javadi, Niloofar
Saadatnia, Mohammad
Vossough, Arastoo
Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title_full Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title_fullStr Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title_full_unstemmed Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title_short Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report
title_sort longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following covid-19 infection: a pediatric case report
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397488/
https://www.ncbi.nlm.nih.gov/pubmed/34517154
http://dx.doi.org/10.1016/j.jneuroim.2021.577704
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