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Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons

A test-negative case-control study was conducted to assess inactivated influenza vaccine effectiveness (VE) in children aged 6 months-17 years. The database was developed from the US Department of Defense Global Respiratory Pathogen Surveillance Program over four consecutive influenza seasons from 2...

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Autores principales: Hu, Wenping, DeMarcus, Laurie S., Sjoberg, Paul A., Robbins, Anthony S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397503/
https://www.ncbi.nlm.nih.gov/pubmed/34450617
http://dx.doi.org/10.1371/journal.pone.0256165
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author Hu, Wenping
DeMarcus, Laurie S.
Sjoberg, Paul A.
Robbins, Anthony S.
author_facet Hu, Wenping
DeMarcus, Laurie S.
Sjoberg, Paul A.
Robbins, Anthony S.
author_sort Hu, Wenping
collection PubMed
description A test-negative case-control study was conducted to assess inactivated influenza vaccine effectiveness (VE) in children aged 6 months-17 years. The database was developed from the US Department of Defense Global Respiratory Pathogen Surveillance Program over four consecutive influenza seasons from 2016 to 2020. A total of 9,385 children including 4,063 medically attended, laboratory-confirmed influenza-positive cases were identified for VE analysis. A generalized linear mixed model with logit link and binomial distribution was used to estimate the VE. The adjusted VE for children was 42% [95% confidence interval (CI): 37–47%] overall, including 55% (95% CI: 47–61%) for influenza A(H1N1)pdm09, 37% (95% CI: 28–45%) for influenza A(H3N2), and 49% (95% CI: 41–55%) for influenza B. The analysis by age groups indicated that the adjusted VE in children aged 6 months-4 years was higher against influenza A(H1N1)pdm09 and influenza B, and comparable against influenza A(H3N2), compared to those in children aged 5–17 years. Further age-stratified analysis showed that the VE against any types of influenza was low and non-significant for children aged 6–11 months (33%; 95% CI:-2-56%), but it was high (54%; 95% CI: 34–67%) in children aged 12–23 months, and then declined linearly with increasing age. In conclusion, the inactivated influenza vaccination was moderately effective against influenza infection, based on the analysis from a large number of children aged 6 months-17 years over multiple influenza seasons.
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spelling pubmed-83975032021-08-28 Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons Hu, Wenping DeMarcus, Laurie S. Sjoberg, Paul A. Robbins, Anthony S. PLoS One Research Article A test-negative case-control study was conducted to assess inactivated influenza vaccine effectiveness (VE) in children aged 6 months-17 years. The database was developed from the US Department of Defense Global Respiratory Pathogen Surveillance Program over four consecutive influenza seasons from 2016 to 2020. A total of 9,385 children including 4,063 medically attended, laboratory-confirmed influenza-positive cases were identified for VE analysis. A generalized linear mixed model with logit link and binomial distribution was used to estimate the VE. The adjusted VE for children was 42% [95% confidence interval (CI): 37–47%] overall, including 55% (95% CI: 47–61%) for influenza A(H1N1)pdm09, 37% (95% CI: 28–45%) for influenza A(H3N2), and 49% (95% CI: 41–55%) for influenza B. The analysis by age groups indicated that the adjusted VE in children aged 6 months-4 years was higher against influenza A(H1N1)pdm09 and influenza B, and comparable against influenza A(H3N2), compared to those in children aged 5–17 years. Further age-stratified analysis showed that the VE against any types of influenza was low and non-significant for children aged 6–11 months (33%; 95% CI:-2-56%), but it was high (54%; 95% CI: 34–67%) in children aged 12–23 months, and then declined linearly with increasing age. In conclusion, the inactivated influenza vaccination was moderately effective against influenza infection, based on the analysis from a large number of children aged 6 months-17 years over multiple influenza seasons. Public Library of Science 2021-08-27 /pmc/articles/PMC8397503/ /pubmed/34450617 http://dx.doi.org/10.1371/journal.pone.0256165 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Hu, Wenping
DeMarcus, Laurie S.
Sjoberg, Paul A.
Robbins, Anthony S.
Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title_full Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title_fullStr Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title_full_unstemmed Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title_short Inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
title_sort inactivated influenza vaccine effectiveness among department of defense beneficiaries aged 6 months-17 years, 2016–2017 through 2019–2020 influenza seasons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397503/
https://www.ncbi.nlm.nih.gov/pubmed/34450617
http://dx.doi.org/10.1371/journal.pone.0256165
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