Cargando…

Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis

OBJECTIVE: Chaihu Jia Longgu Muli decoction (CLMD) is widely used in the treatment of poststroke depression (PSD) in China. Some evidences show that it has advantages, but there lacks reliable evidence. This study aims to systematically evaluate the efficacy and safety of CLMD in the treatment of PS...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Renhong, Song, Ruiwen, Fan, Yihua, Li, Linhui, Zhang, Jiangxin, Zhang, Beijia, Li, Xinju, Wang, Shenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397549/
https://www.ncbi.nlm.nih.gov/pubmed/34457030
http://dx.doi.org/10.1155/2021/7604537
_version_ 1783744640954925056
author Wan, Renhong
Song, Ruiwen
Fan, Yihua
Li, Linhui
Zhang, Jiangxin
Zhang, Beijia
Li, Xinju
Wang, Shenjun
author_facet Wan, Renhong
Song, Ruiwen
Fan, Yihua
Li, Linhui
Zhang, Jiangxin
Zhang, Beijia
Li, Xinju
Wang, Shenjun
author_sort Wan, Renhong
collection PubMed
description OBJECTIVE: Chaihu Jia Longgu Muli decoction (CLMD) is widely used in the treatment of poststroke depression (PSD) in China. Some evidences show that it has advantages, but there lacks reliable evidence. This study aims to systematically evaluate the efficacy and safety of CLMD in the treatment of PSD. METHODS: All randomized controlled trials (RCTs) of CLMD in the treatment of PSD were searched from the following databases: PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Service System (CBM), from their inception to May 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software. RESULTS: A total of 13 RCTs involving 1665 patients were finally included in this study, among which 5 RCTs were oral CLMD alone versus antidepressants, and 8 RCTs were oral CLMD with antidepressants versus antidepressants. Meta-analysis results showed that oral administration of CLMD could improve Hamilton's Depression Scale (HAMD) and the Modified Edinburgh-Scandinavian Stroke Scale (MESSS) scores, improve the Barthel index, and have a low rate of adverse reactions, but there was no significant difference in the total effective rate (p=0.21 > 0.05) and the National Institute of Health Stroke Scale (NIHSS) score (p=0.47 > 0.05) between the antidepressants group and the oral administration of the CLMD group. Oral CLMD combined with antidepressants could improve the total effective rate, HAMD, and MESSS score, but there was no significant difference in Barthel index (p=0.06 > 0.05) and the adverse reaction rate (p=0.14 > 0.05) between the two groups. CONCLUSION: Current evidence suggests that oral CLMD alone or with antidepressants is more effective and safer in the treatment of PSD than oral antidepressants. Due to the limitation of the quality and quantity of the included studies, more high-quality studies are needed to confirm the above conclusion.
format Online
Article
Text
id pubmed-8397549
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-83975492021-08-28 Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis Wan, Renhong Song, Ruiwen Fan, Yihua Li, Linhui Zhang, Jiangxin Zhang, Beijia Li, Xinju Wang, Shenjun Evid Based Complement Alternat Med Review Article OBJECTIVE: Chaihu Jia Longgu Muli decoction (CLMD) is widely used in the treatment of poststroke depression (PSD) in China. Some evidences show that it has advantages, but there lacks reliable evidence. This study aims to systematically evaluate the efficacy and safety of CLMD in the treatment of PSD. METHODS: All randomized controlled trials (RCTs) of CLMD in the treatment of PSD were searched from the following databases: PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Service System (CBM), from their inception to May 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software. RESULTS: A total of 13 RCTs involving 1665 patients were finally included in this study, among which 5 RCTs were oral CLMD alone versus antidepressants, and 8 RCTs were oral CLMD with antidepressants versus antidepressants. Meta-analysis results showed that oral administration of CLMD could improve Hamilton's Depression Scale (HAMD) and the Modified Edinburgh-Scandinavian Stroke Scale (MESSS) scores, improve the Barthel index, and have a low rate of adverse reactions, but there was no significant difference in the total effective rate (p=0.21 > 0.05) and the National Institute of Health Stroke Scale (NIHSS) score (p=0.47 > 0.05) between the antidepressants group and the oral administration of the CLMD group. Oral CLMD combined with antidepressants could improve the total effective rate, HAMD, and MESSS score, but there was no significant difference in Barthel index (p=0.06 > 0.05) and the adverse reaction rate (p=0.14 > 0.05) between the two groups. CONCLUSION: Current evidence suggests that oral CLMD alone or with antidepressants is more effective and safer in the treatment of PSD than oral antidepressants. Due to the limitation of the quality and quantity of the included studies, more high-quality studies are needed to confirm the above conclusion. Hindawi 2021-08-19 /pmc/articles/PMC8397549/ /pubmed/34457030 http://dx.doi.org/10.1155/2021/7604537 Text en Copyright © 2021 Renhong Wan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wan, Renhong
Song, Ruiwen
Fan, Yihua
Li, Linhui
Zhang, Jiangxin
Zhang, Beijia
Li, Xinju
Wang, Shenjun
Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title_full Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title_fullStr Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title_full_unstemmed Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title_short Efficacy and Safety of Chaihu Jia Longgu Muli Decoction in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
title_sort efficacy and safety of chaihu jia longgu muli decoction in the treatment of poststroke depression: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397549/
https://www.ncbi.nlm.nih.gov/pubmed/34457030
http://dx.doi.org/10.1155/2021/7604537
work_keys_str_mv AT wanrenhong efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT songruiwen efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT fanyihua efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT lilinhui efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT zhangjiangxin efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT zhangbeijia efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT lixinju efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis
AT wangshenjun efficacyandsafetyofchaihujialonggumulidecoctioninthetreatmentofpoststrokedepressionasystematicreviewandmetaanalysis