Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midazolam in Healthy Japanese Males

BACKGROUND AND OBJECTIVE: Esaxerenone showed the potential to inhibit and induce activity against cytochrome P450 (CYP) 3A in in vitro studies. We investigated whether repeated administration of 5 mg/day esaxerenone for 14 days influences the pharmacokinetics of midazolam, a sensitive CYP3A substrat...

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Detalles Bibliográficos
Autores principales: Toyama, Kaoru, Furuie, Hidetoshi, Kuroda, Kana, Ishizuka, Tomoko, Okuda, Yasuyuki, Shimizu, Takako, Kato, Manabu, Igawa, Yoshiyuki, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397627/
https://www.ncbi.nlm.nih.gov/pubmed/34383278
http://dx.doi.org/10.1007/s13318-021-00701-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397627/
https://www.ncbi.nlm.nih.gov/pubmed/34383278
http://dx.doi.org/10.1007/s13318-021-00701-4

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