Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies

Avadomide is a cereblon E3 ligase modulator and a potent antitumor and immunomodulatory agent. Avadomide trials are challenged by neutropenia as a major adverse event and a dose-limiting toxicity. Intermittent dosing schedules supported by preclinical data provide a strategy to reduce frequency and...

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Detalles Bibliográficos
Autores principales: Abbiati, Roberto A., Pourdehnad, Michael, Carrancio, Soraya, Pierce, Daniel W., Kasibhatla, Shailaja, McConnell, Mark, Trotter, Matthew W. B., Loos, Remco, Santini, Cristina C., Ratushny, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397660/
https://www.ncbi.nlm.nih.gov/pubmed/34453265
http://dx.doi.org/10.1208/s12248-021-00623-8

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