Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In this study we interrogate 752 NDMM patients using whole genome sequencing (WGS) to investigate the relationship of copy number (CN) signatures...

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Detalles Bibliográficos
Autores principales: Maclachlan, Kylee H., Rustad, Even H., Derkach, Andriy, Zheng-Lin, Binbin, Yellapantula, Venkata, Diamond, Benjamin, Hultcrantz, Malin, Ziccheddu, Bachisio, Boyle, Eileen M., Blaney, Patrick, Bolli, Niccolò, Zhang, Yanming, Dogan, Ahmet, Lesokhin, Alexander M., Morgan, Gareth J., Landgren, Ola, Maura, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397708/
https://www.ncbi.nlm.nih.gov/pubmed/34453055
http://dx.doi.org/10.1038/s41467-021-25469-8

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